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Besides the well\u2010known respiratory symptoms, many neurological manifestations such as anosmia\/ageusia, headaches, dizziness, seizures, and strokes have been documented in hospitalised patients. The neurotropism background of coronaviruses has led to speculation that the neurological complications are caused by the direct invasion of SARS\u2010CoV\u20102 into the nervous system. This invasion is proposed to occur through the infection of peripheral nerves or via systemic blood circulation, termed neuronal and haematogenous routes of invasion, respectively. On the other hand, aberrant immune responses and respiratory insufficiency associated with Covid\u201019 are suggested to affect the nervous system indirectly. Deleterious roles of cytokine storm and hypoxic conditions in blood\u2010brain barrier disruption, coagulation abnormalities, and autoimmune neuropathies are well investigated in coronavirus infections, as well as Covid\u201019. Here, we review the latest discoveries focussing on possible molecular mechanisms of direct and indirect impacts of SARS\u2010CoV\u20102 on the nervous system and try to elucidate the link between some potential therapeutic strategies and the molecular pathways.<\/jats:p>","DOI":"10.1002\/rmv.2334","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T09:56:38Z","timestamp":1644400598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Neurological complications associated with Covid\u201019; molecular mechanisms and therapeutic approaches"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-7335","authenticated-orcid":false,"given":"Mohammad","family":"Mahboubi Mehrabani","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Sciences Faculty of Biological Sciences Kharazmi University  Tehran 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