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The propensity for RNA viruses to replicate in cytosolic compartments has led to an evolutionary arms race and the emergence of cytosolic sensors to recognise and initiate the host innate immune response. Although significant progress has been made in identifying and characterising cytosolic RNA sensors as anti\u2010viral innate immune factors, the potential role for cytosolic DNA sensors in RNA viral infection is only recently being appreciated. Among these, the cyclic GMP\u2010AMP synthase (cGAS)\u2010stimulator of interferon genes (STING) pathway has attracted increasing attention. The cGAS\u2010STING signalling pathway has emerged as a key innate immune signalling axis that is implicated in diverse human diseases from infectious diseases to neurodegeneration and cancer. Here we review the existing literature on RNA viruses and their reciprocal interactions with the cGAS\u2010STING pathway and share insights into RNA virus diversity by touching on the similarities and differences of RNA viral strategies.<\/jats:p>","DOI":"10.1002\/rmv.2343","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T12:42:40Z","timestamp":1646656960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Crosstalk between RNA viruses and DNA sensors: Role of the cGAS\u2010STING signalling pathway"],"prefix":"10.1002","volume":"32","author":[{"given":"Yiyun Michelle","family":"Fan","sequence":"first","affiliation":[{"name":"Center for Heart Lung Innovation St. Paul's Hospital University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Cellular &amp; Physiological Sciences University of British Columbia  Vancouver British Columbia 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