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Oxidative stress induces oxidative damage to lipids, proteins, and DNA, causing tissue damage. Both inflammation and OS contribute to multi\u2010organ failure in severe cases. Magnesium (Mg<jats:sup>2+<\/jats:sup>) regulates many processes, including antioxidant and anti\u2010inflammatory responses, as well as the proper functioning of other micronutrients such as vitamin D. In addition, Mg<jats:sup>2+<\/jats:sup> participates as a second signalling messenger in the activation of T cells. Therefore, Mg<jats:sup>2+<\/jats:sup> deficiency can cause immunodeficiency, exaggerated acute inflammatory response, decreased antioxidant response, and OS. Supplementation with Mg<jats:sup>2+<\/jats:sup> has an anti\u2010inflammatory response by reducing the levels of nuclear factor kappa B (NF\u2010\u03baB), interleukin (IL) \u20106, and tumor necrosis factor alpha. Furthermore, Mg<jats:sup>2+<\/jats:sup> supplementation improves mitochondrial function and increases the antioxidant glutathione (GSH) content, reducing OS. Therefore, Mg<jats:sup>2+<\/jats:sup> supplementation is a potential way to reduce inflammation and OS, strengthening the immune system to manage COVID\u201019. This narrative review will address Mg<jats:sup>2+<\/jats:sup> deficiency associated with a worse disease prognosis, Mg<jats:sup>2+<\/jats:sup> supplementation as a potent antioxidant and anti\u2010inflammatory therapy during and after COVID\u201019 disease, and suggest that randomised controlled trials are indicated.<\/jats:p>","DOI":"10.1002\/rmv.2348","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T11:08:46Z","timestamp":1648724926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Antioxidant\/anti\u2010inflammatory effect of Mg<sup>2+<\/sup> in coronavirus disease 2019 (COVID\u201019)"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3199-8080","authenticated-orcid":false,"given":"Yalith Lyzet","family":"Arancibia\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Facultad de Qu\u00edmica Departamento de Biolog\u00eda Laboratorio F\u2010315 Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4095-754X","authenticated-orcid":false,"given":"Ana Karina","family":"Aranda\u2010Rivera","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Departamento de Biolog\u00eda Laboratorio F\u2010315 Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-5079","authenticated-orcid":false,"given":"Alfredo","family":"Cruz\u2010Gregorio","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Departamento de Biolog\u00eda Laboratorio F\u2010315 Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-4411","authenticated-orcid":false,"given":"Jos\u00e9","family":"Pedraza\u2010Chaverri","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Departamento de Biolog\u00eda Laboratorio F\u2010315 Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"COVID\u201019 Map. 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