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Muscle injury biomarkers are altered during the acute phase of the disease. The cellular damage and hyperinflammatory state induced by severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection may contribute to the persistence of symptoms, hypoxaemia, mitochondrial damage, and dysregulation of the renin\u2010angiotensin system. In addition, the occurrence of cerebrovascular diseases, involvement of the peripheral nervous system, and harmful effects of hospitalisation, such as the use of drugs, immobility, and weakness acquired in the intensive care unit, all aggravate muscle damage. Here, we review the multifactorial mechanisms of muscle tissue injury, aggravating conditions, and associated sequelae in long COVID\u201019.<\/jats:p>","DOI":"10.1002\/rmv.2355","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T03:54:58Z","timestamp":1649822098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Muscle dysfunction in the long coronavirus disease 2019 syndrome: Pathogenesis and clinical approach"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-2770","authenticated-orcid":false,"given":"Camilla Costa","family":"Silva","sequence":"first","affiliation":[{"name":"Center for Biological and Health Sciences State University of Para  Bel\u00e9m Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2995-0136","authenticated-orcid":false,"given":"Clea Nazar\u00e9 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