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This scoping review based on the PubMed, Scopus, and WOS databases aims to identify and summarise all the available evidence regarding the clinical and histopathological presentations and risk factors associated with kidney injury related to CHIK, as well as the clinical impact. Thus, a total of 54 papers were selected from 1606 initial references after applying the defined inclusion criteria. Data on the association between kidney injury and CHIK are scarce, with studies only conducted in the acute phase of the disease, lacking further characterisation. Kidney injury incidence in hospitalised patients using the Kidney Disease Improving Global Outcomes criteria varies from 21% to 45%, being higher among patients with atypical and severe manifestations. Although acute kidney injury does not seem to be related to viraemia, it may be related to higher mortality. Few studies have described the renal histopathological changes in the acute phase of CHIK, with prevalent findings of acute interstitial nephritis with mononuclear infiltrate, glomerular congestion and nephrosclerosis. Only one study assessed the kidney function of patients in the subacute and chronic phases of CHIK. Additionally, individuals with comorbidities, including chronic kidney disease, may be among those with a greater risk of presenting worse outcomes when affected by CHIK. The results described herein may contribute to better understand the relationship between the kidneys and chikungunya virus.<\/jats:p>","DOI":"10.1002\/rmv.2357","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T09:14:21Z","timestamp":1651828461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The relationship between chikungunya virus and the kidneys: A scoping review"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-7044","authenticated-orcid":false,"given":"Denise Maria do Nascimento","family":"Costa","sequence":"first","affiliation":[{"name":"Nephrology Division Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Alves da Cruz","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Internal Medicine Division Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyl Eanes de Barros","family":"Silva","sequence":"additional","affiliation":[{"name":"Pathology Division Federal University of Maranh\u00e3o  S\u00e3o Luiz Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Precil Diego Miranda de Menezes","family":"Neves","sequence":"additional","affiliation":[{"name":"Nephrology Division University of S\u00e3o Paulo School of Medicine  S\u00e3o Paulo Brazil"},{"name":"Nephrology and Dialysis Center, Hospital Alem\u00e3o Oswaldo Cruz  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"Vajgel","sequence":"additional","affiliation":[{"name":"Nephrology Division Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alina Gomes de Mattos","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Nephrology Division Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Barbosa Lyra de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Nephrology Division Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucila Maria","family":"Valente","sequence":"additional","affiliation":[{"name":"Nephrology Division Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Magalh\u00e3es da","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Federal University of Pernambuco  Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(55)90081-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(55)90080-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.01.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(14)60185\u20109"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.64"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210122"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268808001167"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000396"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40104"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900255"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(16)30385\u20101"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw284"},{"issue":"4","key":"e_1_2_12_14_1","first-page":"727","article-title":"A major epidemic of chikungunya virus","volume":"77","author":"Renault P","year":"2005","journal-title":"Infect. 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