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Due to the four different serotypes and ever\u2010mutating RNA genome, it is challenging to develop efficient therapeutics. Early diagnosis is crucial to prevent the severe form of dengue, leading to mortality. In the past decade, rapid advancement in the high throughput sequencing technologies has shed light on the crucial regulating role of non\u2010coding RNAs (ncRNAs), also known as the \u201cdark matter\u201d of the genome, in various pathological processes. In addition to the human host ncRNAs like microRNAs and circular RNAs, DENV also produces ncRNAs such as subgenomic flaviviral RNAs that can modulate the virus life cycle and regulate disease outcomes. This review outlines the advances in understanding the interplay between the human host and DENV ncRNAs, their regulation of the innate immune system of the host, and the prospects of the ncRNAs in clinical applications such as dengue diagnosis and promising therapeutics.<\/jats:p>","DOI":"10.1002\/rmv.2360","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T08:03:53Z","timestamp":1651737833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Host and viral non\u2010coding RNAs in dengue pathogenesis"],"prefix":"10.1002","volume":"32","author":[{"given":"Pandikannan","family":"Krishnamoorthy","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Laboratory of Immunology and Infectious Disease Biology Indian Institute of Science Education and Research (IISER) Bhopal  Bhopal Madhya Pradesh 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