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The enterovirus A71 is a non\u2010enveloped virus of the <jats:italic>Picornaviridae<\/jats:italic> family having a single\u2010stranded positive\u2010sense RNA genome of about 7.4\u00a0kb which encodes the structural and nonstructural proteins. Currently there are no US FDA\u2010approved vaccines or antiviral therapy available against enterovirus A71 infection. Although enterovirus A71 vaccines have been licenced in China, clinically approved vaccines for widespread vaccination programs are lacking. Substantial progress has recently been achieved on understanding the structure and function of enterovirus A71 proteins together with information on the viral genetic diversity and geographic distribution. The present review is intended to provide an overview on our current understanding of the molecular biology and epidemiology of enterovirus A71 which will aid the development of vaccines, therapeutics and other control strategies so as to bolster the preparedness for future enterovirus A71 outbreaks.<\/jats:p>","DOI":"10.1002\/rmv.2361","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T08:04:34Z","timestamp":1651737874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Insight into the Enterovirus A71: A review"],"prefix":"10.1002","volume":"32","author":[{"given":"Robert","family":"Kinobe","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Mathematics and Natural Sciences Bogor Agricultural University  Bogor Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ageng","family":"Wiyatno","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-3389","authenticated-orcid":false,"given":"I. 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