{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:57:53Z","timestamp":1789624673140,"version":"build-2803163510"},"reference-count":134,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Herpes simplex virus type 1 (HSV\u20101) is an important human pathogen with neurotropism. Following lytic infection in mucosal or skin epithelium, life\u2010long latency is established mainly in sensory neurons, which can periodically reactivate by stress, leading to recurrent disease and virus transmission. During the virus's productive infection, the tegument protein VP16, a component of HSV\u20101 virion, is physically associated with two cellular factors, host cell factor\u20101 (HCF\u20101), and POU domain protein Oct\u20101, to construct the VP16\u2010induced complex, which is essential to stimulate immediate early (IE)\u2010gene transcription as well as initiate the lytic programme. Apart from HCF\u20101 and Oct\u20101, VP16 also associates with a series of other host factors, making a VP16\u2010induced regulatory switch to either activate or inactivate virus gene transcription. In addition, VP16 has effects on distinct signalling pathways via binding to various host molecules that are essentially related to innate immune responses, RNA polymerases, molecular chaperones, and virus infection\u2010induced host shutoff. VP16 also functionally compensates for given host factors, such as PPAR\u2010\u03b3 and\n                    <jats:italic>\u00df<\/jats:italic>\n                    \u2010catenin. In this review, we provide an overview of the updated insights on the interplay between VP16 and the host factors that coordinate virus infection.\n                  <\/jats:p>","DOI":"10.1002\/rmv.2394","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T04:45:46Z","timestamp":1662525946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Host factors associated with either VP16 or VP16\u2010induced complex differentially affect HSV\u20101 lytic infection"],"prefix":"10.1002","volume":"32","author":[{"given":"Xiuyan","family":"Ding","sequence":"first","affiliation":[{"name":"Institute of Life Science and Green Development School of Life Science Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9579-2252","authenticated-orcid":false,"given":"Liqian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Life Science and Green Development School of Life Science Hebei University  Baoding China"},{"name":"College of Veterinary Medicine Yangzhou University  Yangzhou China"},{"name":"Key Laboratory of Microbial Diversity Research and Application of Hebei Province College of Life Science Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/343739"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis891"},{"issue":"304","key":"e_1_2_17_4_1","first-page":"1","article-title":"Prevalence of herpes simplex virus type 1 and type 2 in persons aged 14\u201049: United States, 2015\u20102016","author":"McQuillan G","year":"2018","journal-title":"NCHS data Brief"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100714.1997.tb00012.x"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010013\u20100516\u20102"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0025\u20106196(12)61067\u20102"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00139"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12340"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40588\u2010015\u20100020\u20104"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140765"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.07.020"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00516\u201014"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.14.1.8\u201019.1974"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.73.12.9726\u20109733.1999"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02209\u201018"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01616\u201014"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02372\u201017"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010010\u20105600\u2010x"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002852"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2434993"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.05.012"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.19.7596"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(07)70267\u20103"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01468\u201012"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00415\u201019"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.21775\/cimb.041.267"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000352"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007313"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000352"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005877"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.11.4579\u20104589.1989"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00115\u201011"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.11.6779\u20106786.1995"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.80.1.505\u2010513.2006"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u20106976.2011.00320.x"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21175969"},{"issue":"4","key":"e_1_2_17_38_1","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.4049\/jimmunol.134.4.2673","article-title":"Herpes simplex virus type 1 infection of endothelial, epithelial, and fibroblast cells induces a receptor for C3b","volume":"134","author":"Smiley ML","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02007\u201015"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.73.5.3930\u20103940.1999"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.9.4387"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(88)80036\u20109"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0968\u20100004(03)00088\u20104"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201500020"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.6.726"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(88)80035\u20107"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378\u20101119(01)00512\u20101"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.21.14.4700\u20104712.2001"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.03043\u201015"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.103194hh"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365\u2010011\u20100065\u2010y"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025642\u2010z"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2.6.718"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460\u20102075.1989.tb08361.x"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.006"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.13.1692"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.01.023"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2004.04.004"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010062917\u2010012600"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010018\u20100044\u2010z"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02184\u201017"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(93)90386\u20105"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/351588a0"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.5788"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/353569a0"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.10.7013"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.18.9689\u20109696.2004"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2035253100"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg619"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308676100"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.12.5893\u20105904.2002"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00745\u201017"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.79.20.13082\u201013093.2005"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.69.12.7932\u20107941.1995"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01975\u201012"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.06913\u201011"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00810\u201009"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045749"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01575\u201008"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008076"},{"key":"e_1_2_17_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02611"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065132"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01575\u201008"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005145"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00558\u201012"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2051"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960\u20109822(03)00048\u20104"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097\u20102765(03)00034\u20100"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0076\u20106879(01)42565\u20101"},{"key":"e_1_2_17_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.3.1063\u20101068.2004"},{"key":"e_1_2_17_91_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02047\u201007"},{"key":"e_1_2_17_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007331"},{"key":"e_1_2_17_93_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.67.12.7149\u20107160.1993"},{"key":"e_1_2_17_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.6.3768\u20103776.2003"},{"key":"e_1_2_17_95_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01350\u201014"},{"key":"e_1_2_17_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.03180\u201015"},{"key":"e_1_2_17_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.07.020"},{"key":"e_1_2_17_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00818\u201018"},{"key":"e_1_2_17_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.4.2339\u20102346.1994"},{"key":"e_1_2_17_100_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.24.13562\u201013572.2004"},{"key":"e_1_2_17_101_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080091"},{"key":"e_1_2_17_102_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01106\u201010"},{"key":"e_1_2_17_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.020"},{"key":"e_1_2_17_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01440\u201013"},{"key":"e_1_2_17_105_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.16.8411\u20108420.2004"},{"key":"e_1_2_17_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.10.028"},{"key":"e_1_2_17_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153795"},{"key":"e_1_2_17_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.04.018"},{"key":"e_1_2_17_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.002"},{"key":"e_1_2_17_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985\u2010017\u20100709\u20105"},{"key":"e_1_2_17_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02196"},{"issue":"6","key":"e_1_2_17_112_1","first-page":"397","article-title":"Hsp90 inhibitor AT\u2010533 blocks HSV\u20101 nuclear egress and assembly","volume":"164","author":"Li F","year":"2018","journal-title":"J Biochem"},{"key":"e_1_2_17_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio0807\u2010455"},{"key":"e_1_2_17_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010018\u20100066\u2010x"},{"key":"e_1_2_17_115_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.42556"},{"key":"e_1_2_17_116_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.203430"},{"key":"e_1_2_17_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.2.480"},{"key":"e_1_2_17_118_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1455"},{"key":"e_1_2_17_119_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00300\u201011"},{"key":"e_1_2_17_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010578"},{"key":"e_1_2_17_121_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1735208"},{"key":"e_1_2_17_122_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000071"},{"key":"e_1_2_17_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.10.003"},{"key":"e_1_2_17_124_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132846"},{"key":"e_1_2_17_125_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002\u20100145"},{"key":"e_1_2_17_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201034241\u2010w"},{"key":"e_1_2_17_127_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v92.11.4472.423k47_4472_4478"},{"key":"e_1_2_17_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2015.03.002"},{"key":"e_1_2_17_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2501248"},{"key":"e_1_2_17_130_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203310392419"},{"key":"e_1_2_17_131_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m203436200"},{"key":"e_1_2_17_132_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.748640"},{"key":"e_1_2_17_133_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201006\u20102413"},{"key":"e_1_2_17_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2013.09.004"},{"key":"e_1_2_17_135_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.23.23.8462\u20108470.2003"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.2394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmv.2394","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.2394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:53:10Z","timestamp":1692643990000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.2394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":134,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/rmv.2394"],"URL":"https:\/\/doi.org\/10.1002\/rmv.2394","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"2022-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2394"}}