{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:33:30Z","timestamp":1793705610379,"version":"4.5.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A number of countries have implemented universal childhood varicella vaccination programmes over the past 30\u00a0years. However, strategies differ in terms of dosing schedule (one\u2010 or two\u2010dose), type of vaccine(s) recommended (monovalent, quadrivalent measles\u2010mumps\u2010rubella\u2010varicella, or both), age at vaccination, and dosing interval for a two\u2010dose schedule. An overview of reviews was undertaken to assess the existing systematic review evidence of the clinical efficacy\/effectiveness of alternative varicella vaccination strategies. A comprehensive search of databases, registries and grey literature was conducted up to 2 February 2022. Two reviewers independently screened, extracted data and assessed the methodological quality of included reviews. A total of 20 reviews were included in the overview; 17 assessed the efficacy\/effectiveness of one\u2010dose strategies and 10 assessed the efficacy\/effectiveness of two\u2010dose strategies. Although the quality of most reviews was deemed \u2018critically low\u2019, there was clear and consistent evidence that vaccination is very effective at reducing varicella. While the analysis was restricted due to lack of detail in reporting of the reviews, the evidence suggests that two\u2010dose strategies are more efficacious\/effective than one\u2010dose strategies in preventing varicella of any severity, but that both strategies have similar high efficacy\/effectiveness in preventing moderate or severe varicella. Based on this evidence in this overview of reviews, a key consideration for policymakers on the possible introduction of a childhood varicella vaccination programme and the choice between a one\u2010 or two\u2010dose strategy, will be whether the objective of a programme is to prevent varicella of any severity or to prevent moderate to severe varicella.<\/jats:p>","DOI":"10.1002\/rmv.2407","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T17:28:48Z","timestamp":1668533328000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical efficacy and effectiveness of alternative varicella vaccination strategies: An overview of reviews"],"prefix":"10.1002","volume":"33","author":[{"given":"Susan","family":"Ahern","sequence":"first","affiliation":[{"name":"School of Public Health College of Medicine and Health University College Cork  Cork Ireland"},{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-3012","authenticated-orcid":false,"given":"Kieran A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"},{"name":"School of Pharmacy University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Paone","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"},{"name":"Agenas National Agency for Regional Health Services  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Browne","sequence":"additional","affiliation":[{"name":"School of Public Health College of Medicine and Health University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Carrigan","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Harrington","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Economics Cork University Business School University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Teljeur","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ir\u00edn","family":"Ryan","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"},{"name":"Department of Pharmacology &amp; Therapeutics Trinity College Dublin, Trinity Health Sciences  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,15]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"ECDC Guidance. 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