{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:52:12Z","timestamp":1758970332698,"version":"3.41.2"},"reference-count":101,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since May 2022, an outbreak of Mpox in non\u2010endemic countries has become a potential public health threat. The objective of this rapid review was to examine the risk profile and modes of transmission of Mpox. PubMed, Web of Science, and Scopus were searched from inception through July 30 to collect case reports\/series on patients with Mpox infection. For meta\u2010analysis, data on the total number of participants and deaths by binary categories of exposure (age, sex, country, other co\u2010infections or existing conditions, and mode of contagion) were used. A total of 62 studies (4659 cases) were included. Most cases came from Africa (84.3%), followed by Europe (13.9%). In 63.6% of the cases, the mode of contagion was human contact, while 22.8% of the cases were by animal contact, and 13.5% were unknown or not reported. The mortality rate was 6.5% throughout these studies. The risk of mortality was higher in the younger age group (risk difference: 0.19; 95% CI: 0.02\u20130.36), in cases with other co\u2010infections or current chronic conditions (risk difference: 0.03; 95% CI: 0.01\u20130.05) and in the category of low\u2010 and middle\u2010income countries (risk difference: 0.06; 95% CI: 0.05\u20130.08). There were no significant differences with respect to sex or mode of contagion. These results help to understand the major infection pathways and mortality risk profiles of Mpox and underscores the importance of preventing outbreaks in specific settings, especially in settings densely populated by children, such as day care centres and schools.<\/jats:p>","DOI":"10.1002\/rmv.2410","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:23:56Z","timestamp":1669793036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk profile and mode of transmission of Mpox: A rapid review and individual patient data meta\u2010analysis of case studies"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4068-9338","authenticated-orcid":false,"given":"Rodrigo","family":"N\u00fa\u00f1ez\u2010Cort\u00e9s","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Physiotherapy in Motion Multispeciality Research Group (PTinMOTION) University of Valencia  Valencia Spain"},{"name":"Department of Physical Therapy Faculty of Medicine University of Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-8346","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Calatayud","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH\u2010RG) Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7412-7624","authenticated-orcid":false,"given":"Jos\u00e9 Francisco","family":"L\u00f3pez\u2010Gil","sequence":"additional","affiliation":[{"name":"Health and Social Research Center Universidad de Castilla\u2010La Mancha  Cuenca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-5004","authenticated-orcid":false,"given":"Ai","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Research and Development Unit Parc Sanitari Sant Joan de D\u00e9u CIBERSAM ISCIII ICREA  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Casa\u00f1a","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH\u2010RG) Department of Physiotherapy University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-3429","authenticated-orcid":false,"given":"Rub\u00e9n","family":"L\u00f3pez\u2010Bueno","sequence":"additional","affiliation":[{"name":"Exercise Intervention for Health Research Group (EXINH\u2010RG) Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"},{"name":"Department of Physical Medicine and Nursing University of Zaragoza  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6710a5"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"593","article-title":"A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo","volume":"46","author":"Ladnyj ID","year":"1972","journal-title":"Bull World Health Organ"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011720"},{"issue":"27","key":"e_1_2_11_5_1","first-page":"642","article-title":"Update: multistate outbreak of monkeypox\u2013Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003","volume":"52","author":"Centers for Disease Control and Prevention (CDC)","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.190076"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2608.191387"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00228-6"},{"key":"e_1_2_11_9_1","unstructured":"Monkeypox multi\u2010country outbreak. European Centre for Disease Prevention and Control. Accessed August 25 2022.https:\/\/www.ecdc.europa.eu\/en\/monkeypox\u2010outbreak"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit703"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.52225\/narra.v2i3.90"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.04.014"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","unstructured":"Monkeypox.2022. Accessed August 25 2022.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/monkeypox","DOI":"10.1097\/01.NURSE.0000904412.04897.d6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","unstructured":"Allan\u2010BlitzLT CarragherK Sukhija\u2010CohenA LiH KlausnerJD.Laboratory validation and clinical implementation of human monkeypox saliva\u2010based tests.https:\/\/doi.org\/10.1101\/2022.08.08.22278498","DOI":"10.1101\/2022.08.08.22278498"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.08.014"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046\u20104053\u20101\u201010"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2021.06.016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_11_19_1","unstructured":"LDC Identification Criteria & Indicators. Accessed August 23 2022.https:\/\/www.un.org\/development\/desa\/dpad\/least\u2010developed\u2010country\u2010category\/ldc\u2010criteria.html"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjebm\u20102017\u2010110853"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000101821.61387.a5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taz002"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.22.2200421"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.781"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462\u20102920.16129"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(11)61142\u20102"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2508.190112"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2022.102368"},{"issue":"2","key":"e_1_2_11_29_1","first-page":"165","article-title":"Human monkeypox, 1970\u201379","volume":"58","author":"Breman JG","year":"1980","journal-title":"Bull World Health Organ"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27993"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2808.220830"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc060792"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.3.643"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1610.100713"},{"issue":"5","key":"e_1_2_11_35_1","first-page":"569","article-title":"Human monkeypox","volume":"46","author":"Foster SO","year":"1972","journal-title":"Bull World Health Organ"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.22.2200411"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es.2021.26.32.2100745"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0703.017311"},{"issue":"14","key":"e_1_2_11_39_1","first-page":"304","article-title":"Human monkeypox\u2013Kasai Oriental, Zaire, 1996\u20131997","volume":"46","author":"Centers for Disease Control and Prevention (CDC)","year":"1997","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es.2022.27.27.2200471"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e224"},{"issue":"3","key":"e_1_2_11_42_1","first-page":"295","article-title":"Fatal monkeypox in a child in Kikwit, Zaire","volume":"64","author":"Janseghers L","year":"1984","journal-title":"Ann Soc Belg Med Trop"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114328"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/154.4.551"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.2.293"},{"issue":"4","key":"e_1_2_11_46_1","first-page":"465","article-title":"Human monkeypox: secondary attack rates","volume":"66","author":"Jezek Z","year":"1988","journal-title":"Bull World Health Organ"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25348"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13149\u2010016\u20100516\u2010z"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2018.02.010"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.159.11.1022"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.428"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa559"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.03.820"},{"issue":"23","key":"e_1_2_11_54_1","first-page":"537","article-title":"Multistate outbreak of monkeypox\u2013Illinois, Indiana, and Wisconsin, 2003","volume":"52","author":"Centers for Disease Control and Prevention (CDC)","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.40.8.2919\u20102921.2002"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2022.102386"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(88)91580\u20102"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx168"},{"key":"e_1_2_11_59_1","unstructured":"NoeS ZangeS SeilmaierM et\u00a0al.Clinical and virological features of first human Monkeypox cases in Germany.https:\/\/doi.org\/10.21203\/rs.3.rs\u20101725831\/v1"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2206.150579"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214229"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2022.102395"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.28.2200503"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2022.42.38.34715"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.22.2200424"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7114a1"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa032299"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12\u20100758"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.180832"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1086\/425039"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es.2022.27.27.2200499"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.29.2200552"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2022.102394"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.es.2018.23.38.1800509"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2604.191164"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.22.2200422"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab133"},{"issue":"49","key":"e_1_2_11_78_1","first-page":"1168","article-title":"Human monkeypox \u2013 Kasai Oriental, Democratic Republic of Congo, February 1996\u2010October 1997","volume":"46","author":"Centers for Disease Control and Prevention (CDC)","year":"1997","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473\u20103099(19)30294\u20104"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taac072"},{"issue":"4","key":"e_1_2_11_81_1","first-page":"425","article-title":"Smallpox and its post\u2010eradication surveillance","volume":"65","author":"Jezek Z","year":"1987","journal-title":"Bull World Health Organ"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2704.203569"},{"key":"e_1_2_11_83_1","unstructured":"CDC.Interim clinical considerations for use of JYNNEOS and ACAM2000 vaccines during the 2022 U.S. monkeypox outbreak. Centers for Disease Control and Prevention.2022. Accessed November 14 2022.https:\/\/www.cdc.gov\/poxvirus\/monkeypox\/clinicians\/vaccines\/vaccine\u2010considerations.html"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12941\u2010022\u201000527\u20101"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010141"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15\u20100095"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12228"},{"issue":"3","key":"e_1_2_11_88_1","first-page":"263","article-title":"Social determinants of health associated with severity and mortality\u00a0in patients with COVID\u201019","volume":"157","author":"N\u00fa\u00f1ez\u2010Cort\u00e9s R","year":"2021","journal-title":"Gac Med Mex"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh\u20102022\u2010009838"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007791"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2207323"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.7326\/m22\u20101748"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27913"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00927\u201020"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/v2122803"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28218"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010022\u201001949\u2010x"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.15336"},{"key":"e_1_2_11_99_1","unstructured":"ResponseE.Clinical management and infection prevention and control for monkeypox: interim rapid response guidance 10 June 2022.2022. Accessed August 28 2022.https:\/\/www.who.int\/publications\/i\/item\/WHO\u2010MPX\u2010Clinical\u2010and\u2010IPC\u20102022.1"},{"key":"e_1_2_11_100_1","unstructured":"Monkeypox Outbreak Toolbox. Accessed August 28 2022.https:\/\/www.who.int\/emergencies\/outbreak\u2010toolkit\/disease\u2010outbreak\u2010toolboxes\/monkeypox\u2010outbreak\u2010toolbox"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2022.27.24.2200448"},{"key":"e_1_2_11_102_1","unstructured":"Monkeypox \u2010 United Kingdom of Great Britain and Northern Ireland. Accessed August 28 2022.https:\/\/www.who.int\/emergencies\/disease\u2010outbreak\u2010news\/item\/2022\u2010DON383"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.2410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmv.2410","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.2410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T05:35:50Z","timestamp":1711690550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.2410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":101,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/rmv.2410"],"URL":"https:\/\/doi.org\/10.1002\/rmv.2410","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"type":"print","value":"1052-9276"},{"type":"electronic","value":"1099-1654"}],"subject":[],"published":{"date-parts":[[2022,11,29]]},"assertion":[{"value":"2022-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2410"}}