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There are many similarities between SARS\u2010CoV\u20102 and influenza A virus (IAV); both are single\u2010stranded RNA viruses infecting airway epithelial cells and have similar modes of replication and transmission. Like IAVs, SARS\u2010CoV\u20102 infections poses serious challenges due to the lack of effective therapeutic interventions, frequent appearances of new strains of the virus, and development of drug resistance. New approaches to control these infectious agents may stem from cellular factors or pathways that directly or indirectly interact with viral proteins to enhance or inhibit virus replication. One of the emerging concepts is that host cellular factors and pathways are required for maintaining viral genome integrity, which is essential for viral replication. Although IAVs have been studied for several years and many cellular proteins involved in their replication and pathogenesis have been identified, very little is known about how SARS\u2010CoV\u20102 hijacks host cellular proteins to promote their replication. IAV induces apoptotic cell death, mediated by the B\u2010cell lymphoma\u20102 (Bcl\u20102) family proteins in infected epithelia, and the pro\u2010apoptotic members of this family promotes viral replication by activating host cell proteases. This review compares the life cycle and mode of replication of IAV and SARS\u2010CoV\u20102 and examines the potential roles of host cellular proteins, belonging to the Bcl\u20102 family, in SARS\u2010CoV\u20102 replication to provide future research directions.<\/jats:p>","DOI":"10.1002\/rmv.2411","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:18:22Z","timestamp":1669897102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["B\u2010cell lymphoma\u20102 family proteins\u2010activated proteases as potential therapeutic targets for influenza A virus and severe acute respiratory syndrome coronavirus\u20102: Killing two birds with one stone?"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-1245","authenticated-orcid":false,"given":"Sourabh","family":"Soni","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes A.","family":"Mebratu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010020\u201000459\u20107"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(20)30310\u20107"},{"key":"e_1_2_14_4_1","volume-title":"1918 Pandemic (H1N1 Virus)","author":"Centers for Disease Control and Prevention","year":"2019"},{"key":"e_1_2_14_5_1","volume-title":"CDC Estimates of 2009 H1N1 Influenza Cases, Hospitalizations and 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