{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:37:14Z","timestamp":1792521434094,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The safety of new vaccines under development as well as existing vaccines is a key priority for national and international public health agencies. A number of countries have implemented universal childhood varicella vaccination programmes over the past 30\u00a0years. However, strategies differ in terms of the number of doses, type of vaccine(s) recommended, age at vaccination and interval between doses for a two\u2010dose schedule. An overview of reviews was undertaken to assess the existing systematic review evidence of the safety of varicella vaccination strategies. The review was restricted to immunocompetent children aged 9\u00a0months to 6\u00a0years inclusive. A comprehensive search of databases, registries and grey literature was conducted up to 2 February 2022. Two reviewers independently screened, extracted data and assessed the methodological quality of included reviews. Overlap of included reviews was also assessed. A total of 17 reviews, incorporating both the monovalent varicella only and quadrivalent measles\u2010mumps\u2010rubella\u2010varicella (MMRV) vaccines were included in the overview; six assessed the safety of one\u2010dose strategies, four assessed the safety of two\u2010dose strategies and 14 reviews did not specify the dosing strategy. The evidence suggests that mild local and systemic reactions are relatively common with varicella vaccination. Febrile seizures are also possible adverse effects of both the monovalent and quadrivalent MMRV vaccine, but serious adverse reactions are rare. While most reviews contained methodological flaws, and analysis by vaccine type and dosing strategy was restricted due to lack of detail in reporting of the reviews, there was clear and consistent evidence from a substantial evidence base, comprising 34 randomised controlled trials and 62 other primary studies\/reviews, that varicella vaccination is safe.<\/jats:p>","DOI":"10.1002\/rmv.2416","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T06:00:11Z","timestamp":1670565611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Safety of varicella vaccination strategies: An overview of reviews"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-0506","authenticated-orcid":false,"given":"Susan","family":"Ahern","sequence":"first","affiliation":[{"name":"School of Public Health College of Medicine and Health University College Cork  Cork Ireland"},{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4386-3012","authenticated-orcid":false,"given":"Kieran A.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"},{"name":"School of Pharmacy University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Paone","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"},{"name":"Agenas National Agency for Regional Health Services  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Browne","sequence":"additional","affiliation":[{"name":"School of Public Health College of Medicine and Health University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Carrigan","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Harrington","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Economics Cork University Business School University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Teljeur","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ir\u00edn","family":"Ryan","sequence":"additional","affiliation":[{"name":"Health Information and Quality Authority  Dublin Ireland"},{"name":"Department of Pharmacology &amp; Therapeutics Trinity College Dublin Trinity Health Sciences  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"Centers for Disease Control and Prevention.Chickenpox (Varicella) Complications;2021. 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