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In less than three years, an estimated 600 million infections with SARS\u2010CoV\u20102 occurred worldwide, resulting in a pandemic with tremendous impact especially on economic and health sectors. Initially considered a respiratory disease, COVID\u201019, along with its long\u2010term sequelae (long\u2010COVID) rather is a systemic disease. Neurological symptoms like dementia or encephalopathy were reported early during the pandemic as concomitants of the acute phase and as characteristics of long\u2010COVID. An excessive inflammatory immune response is hypothesized to play a major role in this context. However, direct infection of neural cells may also contribute to the neurological aspects of (long)\u2010COVID\u201019. To mainly explore such direct effects of SARS\u2010CoV\u20102 on the central nervous system, human brain organoids provide a useful platform. Infecting these three\u2010dimensional tissue cultures allows the study of viral neurotropism as well as of virus\u2010induced effects on single cells or even the complex cellular network within the organoid. In this review, we summarize the\u00a0experimental studies that used SARS\u2010CoV\u20102\u2010infected human brain organoids\u00a0to\u00a0unravel the complex nature of (long)\u2010COVID\u201019\u2010related neurological manifestations.<\/jats:p>","DOI":"10.1002\/rmv.2430","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T16:25:47Z","timestamp":1676478347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Human brain organoids to explore SARS\u2010CoV\u20102\u2010induced effects on the central nervous system"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-6119","authenticated-orcid":false,"given":"Philipp Niklas","family":"Ostermann","sequence":"first","affiliation":[{"name":"Institute of Virology University Hospital D\u00fcsseldorf Medical Faculty Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf 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