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This systematic review and meta\u2010analysis examined the pooled prevalence of cardiovascular manifestation and cardiac complications in children hospitalised with MIS\u2010C. The PROSPERO register number is CRD42022327212. We included case\u2010report studies, case\u2010control studies, cohort studies, and cross\u2010sectional studies, as well as clinical trials or studies describing cardiac manifestations of MIS\u2010C and its sequelae in a paediatric population. Initially, 285 studies were selected, but there were 154 duplicates, and 81 were excluded because they did not fit the eligibility criteria. Thus, 50 studies were selected for review, and 30 were included in the meta\u2010analysis. A total sample size of 1445 children was included. The combined prevalence of myocarditis or pericarditis was 34.3% (95% CI: 25.0%\u201344.2%). The combined prevalence for echocardiogram anomalies was 40.8% (95% CI: 30.5%\u201351.5%), that of Kawasaki disease presentation was 14.8% (95% CI: 7.5%\u201323.7%), and that of coronary dilation was 15.2% (95% CI: 11.0%\u201319.8%). The rate of electrocardiogram anomalies was 5.3% (95% CI: 0.8%\u201312.3%), and the mortality rate was 0.5% (CI 95%: 0%\u20131.2%). Furthermore, 186 children still had complications at discharge, with a combined prevalence of such long\u2010lasting manifestations of 9.3% (95% CI: 5.6%\u201313.7%). Studies that assess whether these children will have an increased cardiovascular risk with a greater chance of acute myocardial infarction, arrhythmias, or thrombosis will be essential for healthcare planning.<\/jats:p>","DOI":"10.1002\/rmv.2432","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:30:26Z","timestamp":1676745026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cardiac manifestations in children with the multisystem inflammatory syndrome (MIS\u2010C) associated with SARS\u2010CoV\u20102 infection: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"33","author":[{"given":"M\u00e1rcio Antonio Ferreira","family":"Arantes\u00a0Junior","sequence":"first","affiliation":[{"name":"Hospital Infantil Jo\u00e3o Paulo II FHEMIG  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via","family":"Conegundes","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Castello","family":"Branco\u00a0Miranda","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia Stenner Rodrigues","family":"Radicchi Campos","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Fran\u00e7a Vieira","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Daniel","family":"Faleiro","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4683-0176","authenticated-orcid":false,"given":"Marco Ant\u00f4nio","family":"Campos","sequence":"additional","affiliation":[{"name":"Imunologia de Doen\u00e7as Virais Instituto Ren\u00e9 Rachou Funda\u00e7\u00e3o Oswaldo Cruz  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2721-3826","authenticated-orcid":false,"given":"Erna Geessien","family":"Kroon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de V\u00edrus Departamento de Microbiologia Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-940X","authenticated-orcid":false,"given":"Aline Almeida","family":"Bentes","sequence":"additional","affiliation":[{"name":"Hospital Infantil Jo\u00e3o Paulo II FHEMIG  Belo Horizonte Minas Gerais Brazil"},{"name":"Departamento de Pediatria Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)31094\u20101"},{"key":"e_1_2_10_3_1","unstructured":"World Health Organization.Detailed Surveillance Data Dashboard. 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