{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:46:38Z","timestamp":1784310398990,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a scarcity of scientific evidence addressing the outcomes of COVID\u201019 in celiac disease (CD) patients. This systematic review and meta\u2010analysis aimed to evaluate the correlation between pre\u2010existing CD and COVID\u201019. A rigorous literature search was conducted using multiple databases. All eligible observational studies were included from around the globe. The random effect model calculated the pooled prevalence and associated 95% confidence intervals (CI). Mantel\u2010Haenszel odds ratios were produced to report the overall effect size using random effect models for severity and mortality outcomes. Funnel plots, Egger regression tests, and Begg\u2010Mazumdar's rank correlation test were used to appraise publication bias. Data from 11 articles consisting of 44,378 CD patients were obtained. Overall pooled random\u2010effects estimate of SARS\u2010CoV\u20102 infection in CD patients was 4.25% (95% CI, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a098%). Our findings also indicated that pre\u2010existing CD was not associated with an increased risk of hospitalisation with COVID\u201019 illness (OR\u00a0=\u00a01.04, 95% CI 0.87\u20131.24, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%) and mortality due to illness (OR\u00a0=\u00a00.92, 95% CI 0.56\u20131.5, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a045%) compared with patients without pre\u2010existing CD. No significant publication bias was evident in the meta\u2010analysis. The preliminary data from our analysis suggest that SARS\u2010CoV\u20102 infection in patients with pre\u2010existing CD is not associated with an increased risk of hospitalisation or mortality. Additional studies are required to overcome the restrictions of the limited data available at present.<\/jats:p>","DOI":"10.1002\/rmv.2433","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:30:59Z","timestamp":1676745059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and clinical outcomes of COVID\u201019 in patients with pre\u2010existing celiac disease: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-094X","authenticated-orcid":false,"given":"Sawai Singh","family":"Rathore","sequence":"first","affiliation":[{"name":"Dr. Sampurnanand Medical College  Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1353-0428","authenticated-orcid":false,"given":"Felipe","family":"Velasquez\u2010Botero","sequence":"additional","affiliation":[{"name":"Larkin Community Hospital  Miami Florida USA"},{"name":"Universidad CES  Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-532X","authenticated-orcid":false,"given":"Mar\u00eda Alejandra","family":"Nieto\u2010Salazar","sequence":"additional","affiliation":[{"name":"Juan N. Corpas University  Bogot\u00e1 District of Colombia Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Flowers","sequence":"additional","affiliation":[{"name":"All Saints University College of Medicine  Amos Vale Saint Vincent and the Grenadines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Hasan","sequence":"additional","affiliation":[{"name":"Beirut Private Hospital  Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani Kumar","family":"Parashar","sequence":"additional","affiliation":[{"name":"Dr. Sampurnanand Medical College  Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurram","family":"Tanveer","sequence":"additional","affiliation":[{"name":"Washington University of Health and Science  San Pedro Belize"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamam","family":"Aneis","sequence":"additional","affiliation":[{"name":"The Emirates Health Services Alqassimi Hospital  Sharjah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayotunde Isaac","family":"Buremoh","sequence":"additional","affiliation":[{"name":"University College Hospital University of Ibadan  Ibadan Oyo state Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keturah","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Federal High Court Clinic  Abuja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine The Queen Elizabeth Hospital  King's Lynn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Carolina","family":"Toro\u2010Velandia","sequence":"additional","affiliation":[{"name":"Larkin Community Hospital  Miami Florida USA"},{"name":"Juan N. 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