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A systematic literature search of PubMed and Scopus databases was performed to find studies investigating biomarkers of endothelial dysfunction in COVID\u201019 patients. Pooled standardized mean differences and their 95% confidence intervals were calculated for each biomarker using random effect model. 74 studies with 7668 patients were included. In comparison to patients with good outcome, those with poor outcome had higher levels of von Willebrand factor (vWF) (SMD: 0.83, 95% CI: 0.59\u20131.07, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001), vWF:ADAMTS13 (1.23, (0.77\u20131.7), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001), angiopoietin\u20102 (Ang\u20102) (1.06 (0.6\u20131.51), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), E\u2010selectin (1.09 (0.55\u20131.63), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001), P\u2010selectin (0.59 (0.24\u20130.94), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), syndecan\u20101 (0.99 (0.6\u20131.37), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001), mid\u2010regional pro\u2010adrenomedullin (MR\u2010proADM) (1.52 (1.35\u20131.68), <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001), vascular endothelial growth factor (0.27 (0.02\u20130.53), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), soluble fms\u2010like tyrosine kinase\u20101 (sFLT\u20101) (1.93 (0.65\u20133.21), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and lower levels of ADAMTS13 antigen (\u22120.69 (\u22120.9 to \u22120.47) <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001) and activity (\u22120.84 (\u22121.06 to \u22120.61) <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0000). Plasminogen activator inhibitor\u20101 and tissue plasminogen activator levels were not different between the two groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). There were elevated levels of endothelial dysfunction biomarkers in COVID\u201019 patients with poor outcome, indicating their possible role in disease severity and prognosis. In particular, MR\u2010proADM, vWF, syndecan\u20101 and sFLT\u20101 showed a significant association with poor outcome in these patients.<\/jats:p>","DOI":"10.1002\/rmv.2442","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T13:47:30Z","timestamp":1679406450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biomarkers of endothelial dysfunction are associated with poor outcome in COVID\u201019 patients: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"33","author":[{"given":"Alireza","family":"Mohebbi","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Banking School of Allied Medical Sciences Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Haybar","sequence":"additional","affiliation":[{"name":"Department of Cardiology School of Medicine 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