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A comprehensive search was conducted in seven electronic databases (PubMed, Scopus, Web of Science, EMBASE, ProQuest, EBSCOHost, and Cochrane) to identify the original reports on mpox cases in children and adolescents till 15 January 2023. Descriptive reports on probable or laboratory\u2010confirmed mpox in children and adolescents (0\u201317\u00a0years old) were considered eligible. Studies not providing separate data for the above age group and case\u2010control studies were excluded. The primary outcome was pooled proportion of mpox cases among children and adolescents. Proportion meta\u2010analysis and heterogeneity between studies were determined using a restricted maximum likelihood estimator, and a random\u2010effects model was fitted to the data. Sensitivity analysis and subgroup analysis were also conducted. A drapery plot was also provided as a complementary figure to the forest plot. The protocol was prospectively registered with PROSPERO (CRD42023392475). A total of 440 studies were identified, of which 37 were included in the review and 25 in the meta\u2010analysis (62,701 participants with 3306 children and adolescents). The pooled proportion of children and adolescents was 0.46 (95% CI: 0.30\u20130.63, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>:100%). The proportion of children and adolescents was significantly lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) in the ongoing pandemic 0.04 (95% CI: 0.00\u20130.32) than before 2022 0.62 (95% CI: 0.49\u20130.74). The meta\u2010regression showed that the higher the study's sample size, the lower the proportion of children among the mpox cases. Both overall and subgroup heterogeneity were high. Adolescents and children below 5\u00a0years are commonly affected by the ongoing pandemic. In conclusion, the high proportion of children affected by the mpox virus highlights the need for increased research and targeted interventions to prevent and control the spread of the virus in this population.<\/jats:p>","DOI":"10.1002\/rmv.2472","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T08:45:57Z","timestamp":1690965957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A meta\u2010analysis and mapping of global mpox infection among children and adolescents"],"prefix":"10.1002","volume":"33","author":[{"given":"Tarun Kumar","family":"Suvvari","sequence":"first","affiliation":[{"name":"Rangaraya Medical College  Kakinada Andhra Pradesh India"},{"name":"Squad Medicine and Research (SMR)  Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokanpally","family":"Sandeep","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of Hyderabad  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jogender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakasini","family":"Satapathy","sequence":"additional","affiliation":[{"name":"Global Center for Evidence Synthesis  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-1037","authenticated-orcid":false,"given":"Santenna","family":"Chenchula","sequence":"additional","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind P.","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine ESIC Medical College &amp; Hospital  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Aaqib","family":"Shamim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Schlagenhauf","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Travellers' Health, Institute for Epidemiology, Biostatistics and Prevention University of Z\u00fcrich Centre for Travel Medicine MilMedBiol Competence Centre University of Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso J.","family":"Rodr\u00edguez\u2010Morales","sequence":"additional","affiliation":[{"name":"Master of Clinical Epidemiology and Biostatistics Universidad Cient\u00edfica del Sur  Lima Peru"},{"name":"Gilbert and Rose\u2010Marie Chagoury School of Medicine Lebanese American University  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-8714","authenticated-orcid":false,"given":"Ranjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Tribhuvan University Teaching Hospital  Kathmandu Nepal"},{"name":"Dr. D.Y Patil Medical College Hospital and Research Centre Dr. D.Y. 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