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These new infections are mainly the result of sexual intercourse and thus involve cells present on the genital mucosa, such as dendritic cells (DCs), macrophages (M\u00f8) and CD4+ T lymphocytes. Understanding the mechanisms by which HIV interacts with these cells and how HIV exploits these interactions to establish infection in a new human host is critical to the development of strategies to prevent and control HIV transmission. In this review, we explore how HIV has evolved to manipulate some of the physiological roles of these cells, thereby gaining access to strategic cellular niches that are critical for the spread and pathogenesis of HIV infection. The interaction of HIV with DCs, M\u00f8 and CD4+ T lymphocytes, and the role of the intercellular transfer of viral particles through the establishment of the infectious or virological synapses, but also through membrane protrusions such as filopodia and tunnelling nanotubes (TNTs), and cell fusion or cell engulfment processes are presented and discussed.<\/jats:p>","DOI":"10.1002\/rmv.2480","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:56:37Z","timestamp":1694526997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human immunodeficiency virus transmission\u2014Mechanisms underlying the cell\u2010to\u2010cell spread of human immunodeficiency virus"],"prefix":"10.1002","volume":"33","author":[{"given":"Marta","family":"Calado","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Host\u2010Pathogen Interactions Unit Research Institute for Medicines, iMed\u2010ULisboa Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pires","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Host\u2010Pathogen Interactions Unit Research Institute for Medicines, iMed\u2010ULisboa Universidade de Lisboa  Lisboa Portugal"},{"name":"Center for Interdisciplinary Research in Health Cat\u00f3lica Medical School Universidade Cat\u00f3lica Portuguesa  Rio de Mouro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Host\u2010Pathogen Interactions Unit Research Institute for Medicines, iMed\u2010ULisboa Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirina","family":"Santos\u2010Costa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Host\u2010Pathogen Interactions Unit Research Institute for Medicines, iMed\u2010ULisboa Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-0198","authenticated-orcid":false,"given":"Elsa","family":"Anes","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Host\u2010Pathogen Interactions Unit Research Institute for Medicines, iMed\u2010ULisboa Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-7208","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Azevedo\u2010Pereira","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Host\u2010Pathogen Interactions Unit Research Institute for Medicines, iMed\u2010ULisboa Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro729"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08757"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/cia.s2086"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2015.06.004"},{"key":"e_1_2_11_6_1","unstructured":"UNAIDS.2022. 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