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In the systematic review and meta\u2010analysis of patients with ICIs, we assessed the serological response of cancer patients receiving COVID\u201019 vaccine, and explored the risk of immune related adverse events (irAEs). We searched PubMed, EMBASE and Cochrane Library as of 10 June 2023, and included cancer patients who received ICIs and COVID\u201019 vaccine. The systematic review and meta\u2010analysis include cohort study, cross\u2010sectional study and case report. The outcome included the serological response, Spike\u2010specific T\u2010cell response, irAEs and rare adverse events. When possible, the data were analysed by random effect analysis, and the statistical heterogeneity was assessed by Q\u2010test and I<jats:sup>2<\/jats:sup> statistics. We explored the sources of heterogeneity through L\u2019Abbe plots, Galbraith radial plots, and sensitivity analysis. The publication bias was evaluated by Egger's, Begg's linear regression test and funnel plot, and the impact of publication bias was further analysed by trim and fill method. 27 studies were eligible (19 cohort studies, 1 cross\u2010sectional study and 7 case reports), involving 8331 patients (with 4724 receiving ICIs). Most studies used mRNA vaccine (BNT162b2 or mRNA\u20101273). Compared with cancer patients receiving chemotherapy, cancer patients receiving ICIs were significantly more likely to have seroconversion (RR\u00a0=\u00a01.05, 95%CI 1.01\u20131.10, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). There were no statistically significant differences in seroconversion rates when comparing cancer patients receiving ICIs with controls without cancer (RR\u00a0=\u00a00.95, 95%\u2009CI 0.89\u20131.01, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.09) or with cancer patients receiving targeted therapy (RR\u00a0=\u00a01.05, 95% CI 0.79\u20131.39, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.75). The incidence of irAEs in patients receiving ICIs before and after COVID\u201019 vaccination was (21.96%, 95%CI 16.66%\u201328.94%) and (14.88%, 95%CI 8.65%\u201325.57%), respectively. The most common irAEs were endocrine abnormalities, skin disorders, etc. The certainty of evidence was low in cancer patients with ICIs, compared with those receiving chemotherapy, and very low versus controls without cancer. Cancer patients treated with ICIs seem to be able to receive COVID\u201019 vaccine safely without increasing the incidence of irAEs.<\/jats:p>","DOI":"10.1002\/rmv.2495","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T05:07:10Z","timestamp":1701234430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serological response and immune\u2010related adverse events following COVID\u201019 vaccination in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[{"name":"School of Graduates Beijing University of Chinese Medicine  Beijing China"},{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7692-7529","authenticated-orcid":false,"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuancan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhe","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Graduates Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taicheng","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Graduates Beijing University of Chinese Medicine  Beijing China"},{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Graduates Beijing University of Chinese Medicine  Beijing China"},{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ding","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases Chu Hsien\u2010I Memorial Hospital &amp; Tianjin Institute of Endocrinology Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing 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