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We conducted a systematic review and random\u2010effects meta\u2010analysis to evaluate the cumulative incidence and mortality rate of influenza virus\u2010related cardiovascular complications in hospitalized patients. We searched the PubMed and EMBASE databases for studies reporting acute myocardial infarction (AMI), heart failure (HF), arrhythmia of any kind, stroke or transient ischemic attack (TIA), and myocarditis in hospitalized patients with laboratory\u2010confirmed influenza virus infection. Prospective studies, retrospective cohort studies, and randomized controlled trials (RCTs) were included in the analysis. We followed the PRISMA checklist and used 95% confidence intervals (CIs) to report meta\u2010analysis outcomes. This study was registered on PROSPERO (CRD42023427849). After retrieving 2803 studies, we identified 19 studies (18 observational and 1 RCT) with relevant data, and we included 6936 patients in our analysis, of whom 690 (9.9%) developed a cardiovascular outcome of interest. The cumulative incidence of HF was 17.47% (95% CI: 5.06%\u201334.54%), arrhythmia of any kind 6.12% (95% CI: 0.00%\u201321.92%), myocarditis 2.56% (95% CI: 0.66%\u20135.38%), AMI 2.19% (95% CI: 1.03%\u20133.72%), and stroke or TIA 1.14% (95% CI: 0.00%\u20134.05%). The in\u2010hospital mortality rate from cardiovascular events was 1.38% (95% CI: 0.00%\u20134.80%). Cardiovascular complications occur in patients with influenza virus infection, with the cumulative incidence of specific cardiac manifestations varying considerably (1.51%\u201317.47%). Preventive strategies and close clinical monitoring after infection remain a priority.<\/jats:p>","DOI":"10.1002\/rmv.2497","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T15:52:27Z","timestamp":1703173947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cumulative incidence and mortality rate of cardiovascular complications due to laboratory\u2010confirmed influenza virus infection: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"34","author":[{"given":"Konstantinos","family":"Ouranos","sequence":"first","affiliation":[{"name":"Department of Medicine Houston Methodist Research Institute  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanos","family":"Vassilopoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine Warren Alpert Medical School of Brown University Rhode Island Hospital  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Vassilopoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine Warren Alpert Medical School of Brown University Rhode Island Hospital  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Shehadeh","sequence":"additional","affiliation":[{"name":"Department of Medicine Houston Methodist Research Institute  Houston Texas USA"},{"name":"School of Electrical and Computer Engineering National Technical University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-0777","authenticated-orcid":false,"given":"Eleftherios","family":"Mylonakis","sequence":"additional","affiliation":[{"name":"Department of Medicine Houston Methodist Research Institute  Houston Texas USA"},{"name":"Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Influenza (Seasonal). 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