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Several viruses, including human immunodeficiency virus and Japanese encephalitis virus, can use dopaminergic receptors to replicate in the nervous system and are involved in viral neuropathogenesis. In addition, studies suggest that dopaminergic receptors may play a role in the progression and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. When SARS\u2010CoV\u20102 binds to angiotensin\u2010converting enzyme 2 receptors on the surface of neuronal cells, the spike protein of the virus can bind to dopaminergic receptors on neighbouring cells to accelerate its life cycle and exacerbate neurological symptoms. In addition, recent research has shown that dopamine is an important regulator of the immune\u2010neuroendocrine system. Most immune cells express dopamine receptors and other dopamine\u2010related proteins, indicating the importance of dopaminergic immune regulation. The increase in dopamine concentration during SARS\u2010CoV2 infection may reduce immunity (innate and adaptive) that promotes viral spread, which could lead to neuronal damage. In addition, dopaminergic signalling in the nervous system may be affected by SARS\u2010CoV\u20102 infection. COVID \u201019 can cause various neurological symptoms as it interacts with the immune system. One possible treatment strategy for COVID \u201019 patients could be the use of dopamine antagonists. To fully understand how to protect the neurological system and immune cells from the virus, we need to study the pathophysiology of the dopamine system in SARS\u2010CoV\u20102 infection.<\/jats:p>","DOI":"10.1002\/rmv.2506","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T15:04:06Z","timestamp":1704467046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of the relationship between the dopaminergic pathway and severe acute respiratory syndrome coronavirus 2 infection, with related neuropathological features, and potential therapeutic approaches in COVID\u201019 infection"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-1909","authenticated-orcid":false,"given":"Yousef","family":"Rasmi","sequence":"first","affiliation":[{"name":"Cellular and Molecular Research Center Cellular and Molecular Medicine Research Institute Urmia 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