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The purpose of this study is to look at the effectiveness and safety of vaccine platforms against the incidence of COVID\u201019. The literature search was performed on PubMed\/Medline, Cochrane, and clinical <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/trials.gov\">trials.gov<\/jats:ext-link> databases for studies published between 1 January 2020 and 19 February 2022. Preferred Reporting Items for Systemic Review and Meta\u2010Analysis Statement guidelines were followed. Among 284 articles received by keywords, a total of 11 studies were eligible according to the inclusion and exclusion criteria (studies in special populations, e.g., pregnant women, paediatric patients, editorials, case reports, review articles, preclinical and in vitro studies) of the study. A total of 247,186 participants were considered for randomisation at baseline, among them, 129,572 (52.42%) were provided with vaccine (Intervention group) and 117,614 (47.58%) with the placebo (Control group). A pooled fold change estimation of 0.19 (95% CI: 0.12\u20130.31, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) showed significant protection against the incidence of COVID\u201019 in the vaccines received group versus the placebo group. mRNA based, inactivated vaccines and non\u2010replicating viral vector\u2010based vaccines showed significantly protection against the incidence of COVID\u201019 compared to placebo with pooled fold change estimation was 0.08 (95% CI: 0.06\u20130.10), 0.20 (95% CI: 0.14\u20130.29) and 0.36 (95% CI: 0.28\u20130.46), respectively. Injection site discomfort and fatigue were the most common side effect observed in mRNA, non\u2010replicating viral vector, inactivated, and protein subunit\u2010based vaccines. All the approved vaccines were found safe and efficacious but mRNA\u2010based vaccines were found to be more efficacious against SARS\u2010CoV\u20102 than other platforms.<\/jats:p>","DOI":"10.1002\/rmv.2507","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T06:34:39Z","timestamp":1703918079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Safety and efficacy of COVID\u201019 vaccines: A systematic review and meta\u2010analysis of controlled and randomized clinical trials"],"prefix":"10.1002","volume":"34","author":[{"given":"Jayesh","family":"Beladiya","sequence":"first","affiliation":[{"name":"Department of Pharmacology L. M. 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