{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:00:29Z","timestamp":1785798029991,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>First reported in August 2022, the Langya virus (LayV) has emerged as a potential global health threat in the post\u2010COVID\u201019 era. Preliminary reports show that 35 patients near Shandong and Henan, China experienced a febrile acute LayV infection. We conducted this review following the PRISMA protocol to synthesise current knowledge on LayV's characteristics in terms of molecular, clinical, and public health perspectives. This virus belongs to the <jats:italic>Paramyxoviridae<\/jats:italic> family and carries a non\u2010segmented, single\u2010stranded negative\u2010sense RNA genome. Shrews may be the natural reservoir of the virus. Clinical symptoms range from mild flu\u2010like symptoms to severe manifestations involving pneumonia, haematological disorders, and organ dysfunction. Diagnostic methods include PCR and ELISA assays. Despite the absence of established treatments, antiviral drugs such as ribavirin and chloroquine may be useful in some cases. In light of prevention, a comprehensive approach that emphasises multidisciplinary collaboration is crucial for early surveillance and response. Urgent global efforts are needed for vaccine development and preparedness against this potential pandemic threat. As the viral dynamics remain uncertain, a proactive approach is vital to mitigate the impact of not only LayV but also future threats on a large scale in long term.<\/jats:p>","DOI":"10.1002\/rmv.2520","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T15:38:57Z","timestamp":1705937937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A comprehensive review of Langya virus and framework for future zoonotic disease control"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-6974","authenticated-orcid":false,"given":"Dang Huu","family":"Thien","sequence":"first","affiliation":[{"name":"College of Health Sciences VinUniversity  Hanoi Vietnam"},{"name":"Online Research Club  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2137-797X","authenticated-orcid":false,"given":"Hoang Bao","family":"Tran","sequence":"additional","affiliation":[{"name":"Online Research Club  Nagasaki Japan"},{"name":"Le Hong Phong High School for the Gifted  Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1861-7700","authenticated-orcid":false,"given":"Nguyen Ngoc Phuong","family":"Uyen","sequence":"additional","affiliation":[{"name":"College of Health Sciences VinUniversity  Hanoi Vietnam"},{"name":"Online Research Club  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-8189","authenticated-orcid":false,"given":"Huynh Lai Phuong","family":"Thao","sequence":"additional","affiliation":[{"name":"Online Research Club  Nagasaki Japan"},{"name":"Le Hong Phong High School for the Gifted  Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-1138","authenticated-orcid":false,"given":"Huynh Thi My","family":"Tam","sequence":"additional","affiliation":[{"name":"Online Research Club  Nagasaki Japan"},{"name":"School of Medicine and Pharmacy The University of Da Nang  Da Nang Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-0978","authenticated-orcid":false,"given":"Nguyen Khoi","family":"Quan","sequence":"additional","affiliation":[{"name":"College of Health Sciences VinUniversity  Hanoi Vietnam"},{"name":"Online Research Club  Nagasaki Japan"},{"name":"Institute for Global Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-9440","authenticated-orcid":false,"given":"Nguyen Tien","family":"Huy","sequence":"additional","affiliation":[{"name":"Online Research Club  Nagasaki Japan"},{"name":"School of Tropical Medicine and Global Health Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2202705"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ms9.0000000000000322"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42269\u2010023\u201001064\u20103"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28127"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.31646\/gbio.176"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2022.2117874"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039278\u20108"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ms9.0000000000001057"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.52547\/payesh.22.4.483"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28173"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idh.2023.05.004"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28530"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2023.2260561"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000000151"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104896"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010022\u201000670\u20109"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.08.20.554025"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28095"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcac278"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jve.2022.100087"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2022.08.012"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2022.2154188"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/ejh.ejh_50_22"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u20101757775"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl\u20102022\u20100175"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1473\u20103099(19)30634\u20106"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.53388\/fh20221101017"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hcs2.42"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010022\u201002175\u2010z"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00433\u201023"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/hjhs.hjhs_12_23"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/GH9.0000000000000134"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.2520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T04:22:14Z","timestamp":1722486134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.2520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/rmv.2520"],"URL":"https:\/\/doi.org\/10.1002\/rmv.2520","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2520"}}