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We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID\u201019 and oral post\u2010acute\u2010sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia, xerostomia, sialolitis\u2010sialolith, and mucositis. We contend that PD\u2010associated oral microbial dysbiosis involving higher burden of periodontopathic bacteria provide an optimal microenvironment for severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection. These pathogens interact with oral epithelial cells activate molecular or biochemical pathways that promote viral adherence, entry, and persistence in the oral cavity. A repertoire of diverse molecules identifies this relationship including lipids, carbohydrates and enzymes. The S protein of SARS\u2010CoV\u20102 binds to the ACE2 receptor and is activated by protease activity of host furin or TRMPSS2 that cleave S protein subunits to promote viral entry. However, PD pathogens provide additional enzymatic assistance mimicking furin and augment SARS\u2010CoV\u20102 adherence by inducing viral entry receptors ACE2\/TRMPSS, which are poorly expressed on oral epithelial cells. We discuss the mechanisms involving periodontopathogens and host factors that facilitate SARS\u2010CoV\u20102 infection and immune resistance resulting in incomplete clearance and risk for \u2018long\u2010haul\u2019 oral health issues characterising PASC. Finally, we suggest potential diagnostic markers and treatment avenues to mitigate oral PASC.<\/jats:p>","DOI":"10.1002\/rmv.2543","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T21:49:40Z","timestamp":1716500980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["SARS\u2010CoV\u20102, periodontal pathogens, and host factors: The trinity of oral post\u2010acute sequelae of COVID\u201019"],"prefix":"10.1002","volume":"34","author":[{"given":"Joel","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Diagnostic Sciences University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristelle J.","family":"Capistrano","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Illinois Chicago  Chicago Illinois 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