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Of 85%\u201390% cCMV\u2010infected infants without symptoms at birth, 10%\u201315% develop sequelae, most commonly sensorineural hearing loss (SNHL); their childhood neurodevelopmental outcomes are less well understood. Embase and MEDLINE were searched for publications from 16<jats:sup>th<\/jats:sup> September 2016 to 9th February 2024 to identify studies reporting primary data on neurodevelopmental outcomes in children with asymptomatic cCMV (AcCMV), measured using assessment tools or as evaluated by the study investigators, clinicians, educators, or parents. The Newcastle\u2010Ottawa scale was applied to studies to assess risk of bias. Of 28 studies from 18 mostly high\u2010income countries, there were 5\u2010109 children with AcCMV per study and 6\/28 had a mean or median age at last follow\u2010up of \u22655\u00a0years. Children with AcCMV had better neurodevelopmental outcomes than children with symptomatic cCMV in 16\/19 studies. Of 9\/28 studies comparing AcCMV with CMV\u2010uninfected children, six reported similar outcomes whilst three reported differences limited to measures of full\u2010scale intelligence and receptive vocabulary among children with AcCMV and SNHL, or more generally in motor impairment. Common limitations of studies for our question were a lack of cCMV\u2010uninfected controls, heterogeneous definitions of AcCMV, lack of focus on neurodevelopment, selection bias and inadequate follow\u2010up. There was little evidence of children with AcCMV having worse neurodevelopmental outcomes than CMV\u2010uninfected children, but this conclusion is limited by study characteristics and quality; findings highlight the need for well\u2010designed and standardised approaches to investigate long\u2010term sequelae.<\/jats:p>","DOI":"10.1002\/rmv.2555","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T14:10:26Z","timestamp":1718979026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? 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