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The formation of multinucleated RS cells is a product of telomere organisation in a process initiated by telomere aggregate accumulation in mononuclear H cells and may be mediated by latent membrane protein 1 (LMP\u20101) expression. LMP\u20101 is the main oncoprotein of EBV and supports several tumourigenic processes. LMP\u20101 may rescue proapoptotic B\u2010cells through downregulation of B\u2010cell receptor (BCR) components, mimicking and inducing multiple distinct B\u2010cell signalling pathways to promote proliferation and survival, such as Janus kinase\u2010signal transducer and activator of transcription (JAK\u2010STAT), nuclear factor\u2010kappa b (NF\u2010\u043aB), and cellular MYC (c\u2010MYC), and inducing telomere instability mainly through Telomere repeat binding factor 2 (TRF2) downregulation to promote the formation of multinucleated RS cells. This review presents recent discoveries regarding the influence of LMP\u20101 on the surviving cellular signalling, genomic instability and mecanical formation of HRS cells.<\/jats:p>","DOI":"10.1002\/rmv.2561","type":"journal-article","created":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T13:20:06Z","timestamp":1718457606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between Epstein\u2010Barr virus LMP\u20101 and Hodgkin lymphoma LMP\u20101 mechanisms in Hodgkin lymphoma development"],"prefix":"10.1002","volume":"34","author":[{"given":"Leonam Oliver Durval","family":"Oliveira","sequence":"first","affiliation":[{"name":"Virology Section Evandro Chagas Institute  Ananindeua Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Brasil","family":"Costa","sequence":"additional","affiliation":[{"name":"Virology Section Evandro Chagas Institute  Ananindeua 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