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Pivotal for an efficient clinical management, the early diagnosis of dengue\u2010associated liver involvement relies on an accurate description of its clinical and biological characteristics, its prognosis factors, its association with severe dengue and its clinical management. We conducted a systematic review by searching PubMed and Web of Science databases for original case reports, cohort and cross\u2010sectional studies reporting the clinical and\/or biological features of dengue\u2010associated liver involvement. The study was registered in PROSPERO (CRD42021262657). Of the 2552 articles identified, 167 were included. Dengue\u2010associated liver involvement was characterised by clinical features including abdominal pain, hepatomegaly, jaundice, nausea\/vomiting, and an echogenic liver exhibiting hepatocellular necrosis and minimal inflammation. Elevated Aspartate Aminotransferase and Alanine Aminotransferase but also elevated bilirubin, Alkaline Phosphatase, gamma\u2010glutamyl transferase, increased International Normalised Ratio, creatinine and creatine kinase, lower albumin and prolonged prothrombin and activated partial thromboplastin time were prevalent in dengue\u2010associated liver involvement. Cardiovascular and haematological systems were frequently affected, translating in a strong association with severe dengue. Liver involvement was more common in males and older adults. It was associated with dengue virus serotype\u20102 and secondary infections. Early paracetamol intake increased the risk of liver involvement, which clinical management was mostly conservative. In conclusion, this systematic review demonstrates that early monitoring of transaminases, clinical assessment, and ultrasound examination allow an efficient diagnosis of dengue\u2010associated liver involvement, enabling the early identification and management of severe dengue.<\/jats:p>","DOI":"10.1002\/rmv.2564","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T03:39:21Z","timestamp":1719373161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Liver involvement in dengue: A systematic review"],"prefix":"10.1002","volume":"34","author":[{"given":"Valentine","family":"Campana","sequence":"first","affiliation":[{"name":"CIC Antilles Guyane INSERM CIC1424 Fort\u2010de\u2010France France"},{"name":"PCCEI Universit\u00e9 de Montpellier INSERM Etablissement Fran\u00e7ais du Sang Universit\u00e9 des Antilles Montpellier 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