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In recent years, emerging and re\u2010emerging vector\u2010borne diseases have gained attention as they can cause a wide spectrum of neurological manifestations. The neurological manifestations of vector\u2010borne viruses encompass a board spectrum of clinical manifestations, ranging from mild and self\u2010limiting symptoms to severe and life\u2010threatening conditions. Common neurological complications include viral encephalitis, acute flaccid paralysis, aseptic meningitis, and various neuromuscular disorders. The specific viruses responsible for these neurological sequelae vary by geographic region and include Orthoflavivirus nilense, Zika virus, dengue virus, chikungunya virus, Japanese encephalitis virus, and tick\u2010borne encephalitis virus. This review focuses on the pathogenesis of these neurologic complications and highlights the mechanisms by which vector\u2010borne viruses invade the central nervous system and trigger neuroinflammatory responses. Diagnostic challenges and strategies for early detection of neurological manifestations are discussed, emphasising the importance of clinical suspicion and advanced laboratory testing.<\/jats:p>","DOI":"10.1002\/rmv.2571","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T03:58:50Z","timestamp":1721707130000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neurological manifestations of Flaviviridae, Togaviridae, and Peribunyaviridae as vector\u2010borne viruses"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-0810","authenticated-orcid":false,"given":"Mohammed","family":"Alissa","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meshari 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