{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:50:12Z","timestamp":1790895012001,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,10,3]],"date-time":"2001-10-03T00:00:00Z","timestamp":1002067200000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Arenaviruses, such as Lassa fever, establish chronic infections in rodents, leading to incidental transmission to humans. Lassa fever is a clinically severe disease, yet the absence of second attacks implies life\u2010long immunity. The aim of this review is to consider whether such immunity could be provided by vaccines. The South American arenaviruses are controlled by neutralising antibody and a clinical trial of live, attenuated vaccine for Argentinian haemorrhagic fever provided 84% protection. In contrast, there is no evidence for protective humoral immunity against Old World arenaviruses which are controlled by cell\u2010mediated immune responses. Nevertheless, vaccination with Lassa glycoproteins can protect monkeys from disease, implying that protection may be achievable, even though the immunological mechanisms are distinct. Recombinant vaccinia viruses expressing various forms of Lassa glycoproteins can protect both guinea\u2010pigs and primates, while additional protective responses can be mounted against nucleocapsid genes. However, vaccines based upon vaccinia constructs are no longer tenable for African populations with a high seroprevalence of HIV infection. The scientific challenge now remains to find alternative methods of delivering T\u2010cell immunity against glycoproteins from Lassa virus in ways which can overcome the local economic and political hurdles to vaccine development. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rmv.329","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:30:39Z","timestamp":1030249839000},"page":"331-341","source":"Crossref","is-referenced-by-count":53,"title":["Towards a human Lassa fever vaccine"],"prefix":"10.1002","volume":"11","author":[{"given":"S. P.","family":"Fisher\u2010Hoch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,10,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/227174a0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1970.19.680"},{"key":"e_1_2_1_4_2","first-page":"1231","volume-title":"Fields Virology","author":"Bishop DH","year":"1993"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.3.437"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/mpev.1997.0436"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.15.6992-7004.2000"},{"key":"e_1_2_1_8_2","first-page":"441","article-title":"Isolation of an arenavirus closely related to Lassa virus from Mastomys natalensis in south\u2010east Africa","volume":"55","author":"Wulff H","year":"1977","journal-title":"Bull World Health Organ"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71683-6_5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008016724243"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4269\/ajtmh.1974.23.1131","article-title":"Lassa fever in the Eastern Province of Sierra Leone, 1970\u20131972. I. Epidemiologic studies","volume":"23","author":"Fraser DW","year":"1974","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90013-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.38.407"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90147-1"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1987.36.408"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7009.857"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1973.22.773"},{"key":"e_1_2_1_18_2","first-page":"21.16","volume-title":"International Conference on Emerging Infectious Diseases","author":"Allan R","year":"1998"},{"key":"e_1_2_1_19_2","first-page":"265","article-title":"Lassa fever, imported case, Netherlands [news]","volume":"75","year":"2000","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_1_20_2","first-page":"99","article-title":"Lassa fever imported to England","volume":"10","year":"2000","journal-title":"Commun Dis Rep CDR Wkly"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.3.445"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6648.584"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/jama.1990.03450160063030","article-title":"Acute sensorineural deafness in Lassa fever [see comments]","volume":"264","author":"Cummins D","year":"1990","journal-title":"JAMA"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71683-6_2"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(92)90050-J"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-72-3-549"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92335-3"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890120203"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/155.3.456"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.5.2186-2192.2000"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90752-4"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1980030103"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92206-3"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1086\/514211"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90659-7"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.15.6777-6783.2000"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.1.317"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.20.3.486-489.1984"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(85)90278-8"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90767-7"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(88)90033-0"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90525-4"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3028-2_15"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(91)90021-M"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(89)90287-0"},{"issue":"3","key":"e_1_2_1_46_2","first-page":"S291","article-title":"Canarypox virus\u2010based vaccines: prime\u2010boost strategies to induce cell\u2010mediated and humoral immunity against HIV","volume":"14","author":"Tartaglia J","year":"1998","journal-title":"AIDS Res Hum Retroviruses"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.4023707"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1654(199904\/06)9:2<121::AID-RMV240>3.0.CO;2-2"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmv.329","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:41:11Z","timestamp":1696621271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["10.1002\/rmv.329"],"URL":"https:\/\/doi.org\/10.1002\/rmv.329","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}