{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:11:51Z","timestamp":1780333911368,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,4,25]],"date-time":"2002-04-25T00:00:00Z","timestamp":1019692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since 1996, over one hundred cases of variant Creutzfeldt\u2010Jakob disease have appeared, mostly in the United Kingdom. In this review, we summarise the major clinical features of this progressive neurodegenerative condition and compare them with those of sporadic Creutzfeldt\u2010Jakob disease. We emphasise the young age (median 26 years) at presentation and the dominant psychiatric\/behavioural features, particularly depression. Sensory symptoms are present initially in half the cases and florid psychiatric symptoms, such as delusions or hallucinations, are also common. Given these symptoms, many patients present in clinical practice initially to a psychiatrist but are referred to neurologists when neurological signs become apparent. Although the definitive diagnosis remains neuropathological, a confident pre\u2010mortem diagnosis is now possible when the \u2018pulvinar sign\u2019 is seen on magnetic resonance imaging studies. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rmv.345","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:24:15Z","timestamp":1030317855000},"page":"143-150","source":"Crossref","is-referenced-by-count":25,"title":["Clinical features of variant Creutzfeldt\u2010Jakob disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Colm","family":"Henry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,4,25]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91412-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200005)47:5<575::AID-ANA4>3.0.CO;2-W"},{"key":"e_1_2_1_4_2","first-page":"372","article-title":"Uber eine der multiplen sklerose klinisch nahenstehende erkrankung des zentralnervensystems (spastiche pseudosklerose) mit bemerkswertem anatomishen befunde","volume":"13","author":"Jakob A","year":"1921","journal-title":"Medizinische Klinik"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3839.388"},{"key":"e_1_2_1_6_2","unstructured":"Department of Environment Food and Rural Affairs.Bovine Spongiform Encephalopathy in Great Britain: a progress report.2001."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/39057"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/38925"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1999.7640203.x"},{"key":"e_1_2_1_10_2","first-page":"17","volume-title":"Prions: Novel Infectious Agents Causing Scrapie and Creutzfeldt\u2010Jakob Disease","author":"Prusiner SB","year":"1987"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01342-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13239"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410390613"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.6.1197"},{"key":"e_1_2_1_15_2","first-page":"296","article-title":"Variant Creutzfeldt\u2010Jakob disease in Hong Kong","volume":"7","author":"Kay R","year":"2001","journal-title":"HKMJ"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.7.749"},{"key":"e_1_2_1_17_2","first-page":"465","volume-title":"Prion Biology and Diseases","author":"Will RG","year":"1999"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07472-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1192\/pb.23.5.264"},{"key":"e_1_2_1_20_2","article-title":"Sensory features of variant Creutzfeldt\u2010Jakob disease","author":"Macleod MA","year":"2001","journal-title":"Neurology"},{"key":"e_1_2_1_21_2","first-page":"744","article-title":"Use of 14\u20103\u20103 and other brain\u2010specific proteins in CSF in the diagnosis of variant Creutzfeldt\u2010Jakob disease","volume":"2001","author":"Green AJE","year":"2001","journal-title":"JNNP"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02140-1"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2001.0771"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)24002-X"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1994.0036"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.325"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161274798"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)11419-3"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.343"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmv.345","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T13:09:52Z","timestamp":1700399392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,25]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1002\/rmv.345"],"URL":"https:\/\/doi.org\/10.1002\/rmv.345","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,25]]}}}