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They confer clonability in soft agarose, tumorigenicity in immunodeficient mice, resistance to apoptosis and induction of interleukin (IL)\u201010, which acts as an autocrine growth factor of BL cells. Furthermore, we demonstrated that EBERs confer resistance to interferon (IFN)\u2010\u03b1\u2010induced apoptosis by inhibition of double\u2010stranded (ds) RNA\u2010activated protein kinase (PKR), which is the key mediator of the antiviral effect of IFN\u2010\u03b1. These studies provide a new notion that RNA molecules contribute to oncogenesis. Copyright \u00a9 2002 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rmv.363","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T22:57:40Z","timestamp":1034117860000},"page":"321-326","source":"Crossref","is-referenced-by-count":57,"title":["The role of Epstein\u2013Barr virus\u2010encoded small RNAs (EBERs) in oncogenesis"],"prefix":"10.1002","volume":"12","author":[{"given":"Asuka","family":"Nanbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,8,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67236-1_14"},{"key":"e_1_2_1_3_2","first-page":"2397","volume-title":"Fields Virology","author":"Rickinson 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