{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:30:29Z","timestamp":1791891029126,"version":"4.3.4"},"reference-count":151,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,8,10]],"date-time":"2004-08-10T00:00:00Z","timestamp":1092096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human cytomegalovirus (HCMV) clinical isolates display genetic polymorphisms in multiple genes. Some authors have suggested that those polymorphisms may be implicated in HCMV\u2010induced immunopathogenesis, as well as in strain\u2010specific behaviours, such as tissue\u2010tropism and ability to establish persistent or latent infections. This review summarises the features of the main clustered HCMV polymorphic open reading frames and also briefly cites other variable <jats:italic>loci<\/jats:italic> within the viral genome. The implications of gene polymorphisms are discussed in terms of potentially advantageous higher fitness obtained by the strain, but also taking into account that the published data are often speculative. The last section of this review summarises and critically analyses the main literature reports about the linkage of strain specific genotypes with clinical manifestations of HCMV disease in different patient populations affected by severe cytomegalovirus infections, namely immunocompromised subjects and congenitally infected newborns. Copyright \u00a9 2004 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/rmv.438","type":"journal-article","created":{"date-parts":[[2004,8,10]],"date-time":"2004-08-10T10:16:17Z","timestamp":1092132977000},"page":"383-410","source":"Crossref","is-referenced-by-count":130,"title":["Genetic polymorphisms among human cytomegalovirus (HCMV) wild\u2010type strains"],"prefix":"10.1002","volume":"14","author":[{"given":"Sara","family":"Pignatelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Dal","family":"Monte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Rossini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Landini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.Supplement_7.S701"},{"key":"e_1_2_1_3_2","first-page":"29","article-title":"Detection of human cytomegalovirus","volume":"49","author":"Huang ES","year":"1976","journal-title":"Yale J Biol Med"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.6.1599"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1128\/iai.21.1.151-157.1978","article-title":"Analysis of antigenic diversity among human cytomegaloviruses by kinetic neutralization tests with high\u2010titered rabbit antisera","volume":"21","author":"Waner JL","year":"1978","journal-title":"Infect Immun"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(96)02127-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-9942-2"},{"key":"e_1_2_1_8_2","volume-title":"Virology","author":"Mocarski ES","year":"2001"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74980-3_6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.1.78-83.1996"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/jvi.41.2.462-477.1982","article-title":"Temporal patterns of human cytomegalovirus transcription: mapping the viral RNAs synthesized at immediate early, early, and late times after infection","volume":"41","author":"Wathen MW","year":"1982","journal-title":"J Virol"},{"key":"e_1_2_1_12_2","volume-title":"Virology","author":"Stinski MF","year":"1990"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-10-2179"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000150510","article-title":"Human cytomegalovirus glycoproteins","volume":"9","author":"Britt WJ","year":"1996","journal-title":"Intervirology"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1575"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1291"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1290"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1128\/jvi.64.6.2922-2931.1990","article-title":"Sequence requirements for proteolytic processing of glycoprotein B of human cytomegalovirus strain Towne","volume":"64","author":"Spaete RR","year":"1990","journal-title":"J Virol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.63.1.403-410.1989"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.6.1229"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(92)90771-G"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.4.769"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199805)55:1<75::AID-JMV12>3.0.CO;2-Z"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/515262"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.1.179"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-2516(98)80086-1"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200008)61:4<481::AID-JMV11>3.0.CO;2-H"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-6-1495"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.21.10841-10848.2002"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1128\/JCM.36.12.3662-3669.1998","article-title":"Sequence variation within three important cytomegalovirus gene regions in isolates from four different patient populations","volume":"36","author":"Zweygberg Wirgart B","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_31_2","first-page":"26","article-title":"The product of human cytomegalovirus (HCMV) UL73 is a new polymorphic structural glycoprotein (gpUL73)","volume":"4","author":"Dal Monte P","year":"2001","journal-title":"J Hum Virol"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01310750"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.24.11881-11892.2000"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.66.3.1761-1764.1992"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-74-2-255"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(85)90018-8"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.17.7720-7729.2000"},{"key":"e_1_2_1_38_2","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1128\/jcm.29.11.2494-2502.1991","article-title":"Comparative sequence analysis of human cytomegalovirus strains","volume":"29","author":"Lehner R","year":"1991","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-11-2777"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-002-0810-x"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2334032100"},{"key":"e_1_2_1_42_2","unstructured":"ShenS ShimamuraM WangS BrittWJ LuS.Co\u2010expression of HCMV glycoproteins gM and gN by DNA immunization induced anti\u2010gM\/gN complex antibody which can effectively neutralize AD169 infectionin vitro. In9th International Cytomegalovirus Workshop and 1stInternational \u03b2\u2010herpesvirus Workshop 2003 Maastricht The Netherlands 106."},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18704-0"},{"key":"e_1_2_1_44_2","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1128\/JVI.72.10.8191-8197.1998","article-title":"The human cytomegalovirus UL74 gene encodes the third component of the glycoprotein H\u2010 L\u2010containing envelope complex","volume":"72","author":"Huber MT","year":"1998","journal-title":"J Virol"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.5.3886-3892.1999"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-7-1537"},{"key":"e_1_2_1_47_2","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1128\/jvi.65.9.5124-5128.1991","article-title":"Anti\u2010idiotype antibodies that mimic gp86 of human cytomegalovirus inhibit viral fusion but not attachment","volume":"65","author":"Keay S","year":"1991","journal-title":"J Virol"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.3.604"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-10-2693"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1194"},{"key":"e_1_2_1_51_2","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1128\/jvi.71.4.3090-3097.1997","article-title":"Glycoprotein H\u2010related complexes of human cytomegalovirus: identification of a third protein of the gCIII complex","volume":"71","author":"Li L","year":"1997","journal-title":"J Virol"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2001.1274"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2003.09.036"},{"key":"e_1_2_1_54_2","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1128\/JVI.73.12.10040-10050.1999","article-title":"Human cytomegalovirus UL144 open reading frame: sequence hypervariability in low\u2010passage clinical isolates","volume":"73","author":"Lurain NS","year":"1999","journal-title":"J Virol"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1086\/344238"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2006"},{"key":"e_1_2_1_57_2","first-page":"82","article-title":"Deletion mutants in human cytomegalovirus glycoprotein US9 are impaired in cell\u2010cell transmission and in altering tight junctions of polarized human retinal pigment epithelial cells","volume":"99","author":"Pereira L","year":"1995","journal-title":"Scand J Infect Dis"},{"key":"e_1_2_1_58_2","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1128\/jvi.70.12.8402-8410.1996","article-title":"Accessory human cytomegalovirus glycoprotein US9 in the unique short component of the viral genome promotes cell\u2010to\u2010cell transmission of virus in polarized epithelial cells","volume":"70","author":"Maidji E","year":"1996","journal-title":"J Virol"},{"key":"e_1_2_1_59_2","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1128\/JVI.72.7.5717-5727.1998","article-title":"A novel human cytomegalovirus glycoprotein, gpUS9, which promotes cell\u2010to\u2010cell spread in polarized epithelial cells, colocalizes with the cytoskeletal proteins E\u2010cadherin and F\u2010actin","volume":"72","author":"Maidji E","year":"1998","journal-title":"J Virol"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.11.5748-5758.2002"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1086\/367900"},{"key":"e_1_2_1_62_2","doi-asserted-by":"crossref","first-page":"8158","DOI":"10.1128\/JVI.72.10.8158-8165.1998","article-title":"Functional analysis of the human cytomegalovirus US28 gene by insertion mutagenesis with the green fluorescent protein gene","volume":"72","author":"Vieira J","year":"2003","journal-title":"J Virol"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5320.1874"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050169"},{"key":"e_1_2_1_65_2","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1128\/jvi.70.10.7198-7208.1996","article-title":"The human cytomegalovirus UL37 immediate early regulatory protein is an integral membrane N\u2010glycoprotein which traffics through the endoplasmic reticulum and Golgi apparatus","volume":"70","author":"Al\u2010Barazi HO","year":"1996","journal-title":"J Virol"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9212"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0726"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-7-1569"},{"key":"e_1_2_1_69_2","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1128\/jvi.67.9.5514-5521.1993","article-title":"Translational inhibition mediated by a short upstream open reading frame in the human cytomegalovirus gpUL4 (gp48) transcript","volume":"67","author":"Degnin CR","year":"1993","journal-title":"J Virol"},{"key":"e_1_2_1_70_2","doi-asserted-by":"crossref","first-page":"8330","DOI":"10.1128\/JVI.73.10.8330-8337.1999","article-title":"Translational effects of mutations and polymorphisms in a repressive upstream open reading frame of the human cytomegalovirus UL4 gene","volume":"73","author":"Alderete JP","year":"1999","journal-title":"J Virol"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1086\/317939"},{"key":"e_1_2_1_72_2","first-page":"3","volume-title":"Multidisciplinary Approach to Understanding Cytomegalovirus","author":"Stinski MF","year":"1993"},{"key":"e_1_2_1_73_2","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/jcm.30.4.955-960.1992","article-title":"Variations in the cytomegalovirus major immediate\u2010early gene found by direct genomic sequencing","volume":"30","author":"Brytting M","year":"1992","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004300050055"},{"key":"e_1_2_1_75_2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1128\/jcm.32.5.1402-1405.1994","article-title":"Identification of human cytomegalovirus strain with immediate\u2010early (IE) antigen\u2010specific monoclonal antibody is prevented by point mutation in IE gene","volume":"32","author":"Zipeto D","year":"1994","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0197(96)00258-9"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(98)00083-5"},{"key":"e_1_2_1_78_2","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1128\/jcm.28.12.2602-2607.1990","article-title":"Comparative analysis of human cytomegalovirus a\u2010sequence in multiple clinical isolates by using polymerase chain reaction and restriction fragment length polymorphism assays","volume":"28","author":"Zaia JA","year":"1990","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_79_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.2.286"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.4.904"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.6.1500"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.3.576"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117648"},{"key":"e_1_2_1_84_2","first-page":"240","volume-title":"Herpesvirus Transcription and its Control","author":"Stinski MF","year":"1991"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.659"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1159\/000150504"},{"key":"e_1_2_1_87_2","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1099\/0022-1317-79-12-3039","article-title":"Strong conservation of the constitutive activity of the IE1\/2 transcriptional control region in wild\u2010type strains of human cytomegalovirus","volume":"79","author":"Sorg G","year":"1998","journal-title":"J Gen Virol"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050019"},{"key":"e_1_2_1_89_2","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1128\/JVI.73.8.6265-6270.1999","article-title":"Numerous length polymorphisms at short tandem repeats in human cytomegalovirus","volume":"73","author":"Davis CL","year":"1999","journal-title":"J Virol"},{"key":"e_1_2_1_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-5274(99)80053-8"},{"key":"e_1_2_1_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(96)01016-9"},{"key":"e_1_2_1_92_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9839"},{"key":"e_1_2_1_93_2","unstructured":"Arav\u2010BogerR WilloughbyRE PassRF et al.Evidence for multiple infections and pathogenic variants of the TNF\u03b1R (UL144) and chemokine (US28) receptor genes of HCMV in neonatal disease. In8th International cytomegalovirus Conference Asilomar Monterey\u2010CA.2001;35."},{"key":"e_1_2_1_94_2","unstructured":"LurainNS KapellKS WinkfieldE PaintsilJ BremerJW.Strain\u2010specific sequence variability of human cytomegalovirus clinical strains. In24th International Herpesvirus Workshop Boston MA USA.1999;11.027."},{"key":"e_1_2_1_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.1.184"},{"key":"e_1_2_1_96_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.5.2097"},{"key":"e_1_2_1_97_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.23.11099-11107.2000"},{"key":"e_1_2_1_98_2","doi-asserted-by":"publisher","DOI":"10.1086\/315445"},{"key":"e_1_2_1_99_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200010)62:2<117::AID-JMV1>3.0.CO;2-L"},{"key":"e_1_2_1_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10383"},{"key":"e_1_2_1_101_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.5.855"},{"key":"e_1_2_1_102_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890290212"},{"key":"e_1_2_1_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(90)90072-N"},{"key":"e_1_2_1_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.2.878-886.1999"},{"key":"e_1_2_1_105_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-9-2375"},{"key":"e_1_2_1_106_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.3.876"},{"key":"e_1_2_1_107_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199708)52:4<451::AID-JMV18>3.0.CO;2-J"},{"key":"e_1_2_1_108_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-11-2913"},{"key":"e_1_2_1_109_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0040"},{"key":"e_1_2_1_110_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-4-983"},{"key":"e_1_2_1_111_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01311179"},{"key":"e_1_2_1_112_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.3.1303-1311.1992"},{"key":"e_1_2_1_113_2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/oxfordjournals.aje.a112549","article-title":"Antigenic relatedness of strains of human cytomegalovirus","volume":"107","author":"Zablotney S","year":"1978","journal-title":"Am J Epidemiol"},{"key":"e_1_2_1_114_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441804"},{"key":"e_1_2_1_115_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605293142205"},{"key":"e_1_2_1_116_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-80-11-2867"},{"key":"e_1_2_1_117_2","doi-asserted-by":"publisher","DOI":"10.1086\/322630"},{"key":"e_1_2_1_118_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/cdli.4.5.515-518.1997","article-title":"Distinct genotypic distributions of cytomegalovirus (CMV) envelope glycoprotein in bone marrow and renal transplant recipients with CMV disease","volume":"4","author":"Woo PC","year":"1997","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_1_119_2","doi-asserted-by":"publisher","DOI":"10.1086\/515672"},{"key":"e_1_2_1_120_2","doi-asserted-by":"publisher","DOI":"10.1086\/341071"},{"key":"e_1_2_1_121_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(200005)61:1<138::AID-JMV22>3.0.CO;2-#"},{"key":"e_1_2_1_122_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.1999.010206.x"},{"key":"e_1_2_1_123_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a025629"},{"key":"e_1_2_1_124_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.24.10015"},{"key":"e_1_2_1_125_2","doi-asserted-by":"publisher","DOI":"10.1266\/jjg.69.481"},{"key":"e_1_2_1_126_2","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1128\/jvi.71.3.2555-2561.1997","article-title":"Host\u2010specific driving force in human immunodeficiency virus type 1 evolution in vivo","volume":"71","author":"Zhang L","year":"1997","journal-title":"J Virol"},{"key":"e_1_2_1_127_2","first-page":"418","article-title":"Simple method for estimating the number of synonymous and non synonymous nucleotide substitutions","volume":"3","author":"Nei M","year":"1986","journal-title":"Mol Biol Evol"},{"key":"e_1_2_1_128_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511623486"},{"key":"e_1_2_1_129_2","doi-asserted-by":"publisher","DOI":"10.1089\/aid.1998.14.533"},{"key":"e_1_2_1_130_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199609)50:1<31::AID-JMV7>3.0.CO;2-U"},{"key":"e_1_2_1_131_2","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1128\/jcm.30.9.2307-2310.1992","article-title":"Effect of interstrain variation on diagnostic DNA amplification of the cytomegalovirus major immediate\u2010early gene region","volume":"30","author":"Chou S","year":"1992","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_132_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050072"},{"key":"e_1_2_1_133_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.1.3.401"},{"key":"e_1_2_1_134_2","first-page":"117","article-title":"Direct DNA immunization of mice with plasmid DNA encoding the tegument protein pp65 (ppUL83) of human cytomegalovirus induces high levels of circulating antibody to the encoded protein","volume":"99","author":"Pande H","year":"1998","journal-title":"Scand J Infect Dis"},{"key":"e_1_2_1_135_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.13.6132-6146.2000"},{"key":"e_1_2_1_136_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-7-525"},{"key":"e_1_2_1_137_2","first-page":"121","article-title":"Vaccination against cytomegalovirus","volume":"17","author":"Plotkin SA","year":"2001","journal-title":"Arch Virol"},{"key":"e_1_2_1_138_2","doi-asserted-by":"publisher","DOI":"10.1086\/317654"},{"key":"e_1_2_1_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(98)00173-6"},{"key":"e_1_2_1_140_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199909)59:1<98::AID-JMV16>3.0.CO;2-A"},{"key":"e_1_2_1_141_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200303280-00018"},{"key":"e_1_2_1_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00236-6"},{"key":"e_1_2_1_143_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-002-0941-0"},{"key":"e_1_2_1_144_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549609037937"},{"key":"e_1_2_1_145_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.2872-2877.2003"},{"key":"e_1_2_1_146_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10488"},{"key":"e_1_2_1_147_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199812270-00010"},{"key":"e_1_2_1_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00006-3"},{"key":"e_1_2_1_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(01)00238-4"},{"key":"e_1_2_1_150_2","doi-asserted-by":"publisher","DOI":"10.1086\/315770"},{"key":"e_1_2_1_151_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(00)00188-8"},{"key":"e_1_2_1_152_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2070"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frmv.438","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T21:07:05Z","timestamp":1700255225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,10]]},"references-count":151,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1002\/rmv.438"],"URL":"https:\/\/doi.org\/10.1002\/rmv.438","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8,10]]}}}