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Different immune abnormalities have been associated with measles, including disappearance of delayed\u2010type hypersensitivity reactions, impaired lymphocyte and antigen\u2010presenting cell functions, down\u2010regulation of pro\u2010inflammatory interleukin 12 production and altered interferon \u03b1\/\u03b2 signalling pathways. Several MV proteins have been suggested to hinder immune functions: hemagglutinin, fusion protein, nucleoprotein and the non\u2010structural V and C proteins. This review will focus on the novel functions attributed to MV proteins in the immunosuppression associated with measles. Here, we highlight new advances in the field, emphasising the interaction between MV proteins and their cellular targets, in particular the cell membrane receptors, CD46, CD150, TLR2 and Fc\u03b3RII in the induction of immunological abnormalities associated with measles. 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