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Therefore, in this meta\u2010analysis, we focused on the impact of various viral infections on male infertility. We searched PubMed, Embase, Web of Science and Cochrane Library on 20 October 2023. And included 135 studies involving 30,298 men of reproductive age. We found that the human papilloma virus (HPV)\u2010infected group had a significantly higher DNA fragmentation index (DFI) than the non\u2010infected group, with a mean difference (MD) of 5.64 (95% CI: 3.74\u20137.54). Conversely, the HPV\u2010infected group had significantly lower sperm count, concentration, viability and normal morphology. Other viruses that affect semen quality include hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). HBV significantly decreased fertilization rate, with an odds ratio (OR) of 0.86 (95% CI: 0.76\u20130.99). HPV associated with lower clinical pregnancy rate (OR: 0.31 [95% CI: 0.16\u20130.62]) and higher miscarriage rate (OR: 5.28 [95% CI: 2.02\u201313.78]). Additionally, the fertility treatment group had a significantly higher rate of HPV infection (OR: 1.85 [95% CI: 1.10\u20133.12]) and adeno\u2010associated virus (AAV) infection (OR: 8.49 [95% CI: 2.66\u201327.10]) than the fertility group. Conclusively, most viral infections affect semen quality, while HBV and HPV may affect assisted reproductive technology (ART) outcomes. HPV and AAV are risk factors for infertility.<\/jats:p>","DOI":"10.1002\/rmv.70002","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T02:24:28Z","timestamp":1731551068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Association Between Male Viral Infections and Infertility: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2971-4537","authenticated-orcid":false,"given":"Yan","family":"Guo","sequence":"first","affiliation":[{"name":"Faculty of Life Science and Technology Kunming University of Science and Technology  Kunming China"},{"name":"Department of Reproductive Gynecology The First People's Hospital of Yunnan Province  Kunming China"},{"name":"Department of Reproductive Gynecology The Affiliated Hospital of Kunming University of Science and Technology  Kunming 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