{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:03:13Z","timestamp":1772258593597,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>As humanity grapples with the COVID\u201019 pandemic caused by the novel SARS\u2010CoV\u20102 virus, the rising threats of the MPox virus (MPXV) in 2022 and 2024 have shown signs of global transmission and the potential to spark another pandemic. Though MPXV has been present for over 5\u00a0decades, with cases traditionally confined to endemic regions in West and Central Africa, recent outbreaks have occurred in multiple non\u2010endemic regions, declaring itself as a Public Health Emergency of International Concern. This study aims to examine the patterns of MPXV transmission, its zoonotic potential, associated complications, and viable strategies to control its spread.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study examines recent outbreak data, case reports, and literature on MPXV transmission, emphasising zoonotic pathways and healthcare\u2010associated cases. A bibliometric analysis has also been performed to deepen the understanding and identify emerging research trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The findings suggest that while MPXV has traditionally been endemic in certain regions of Africa, recent outbreaks indicate an increased transmission risk in non\u2010endemic countries, raising concerns about potential global spread. Data reveals that much of the transmission has occurred within healthcare settings. Additionally, global research on the outbreak remains limited and requires further exploration from various perspectives, emphasising the need for prompt intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Containing MPXV's spread is essential to prevent another potential pandemic. Effective management and control strategies, including enhanced surveillance, public health interventions, and targeted education within at\u2010risk communities, are critical to mitigate the spread and impact of MPXV globally. This study advocates for a proactive approach to MPXV control to avoid its escalation into a widespread health crisis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/rmv.70015","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T01:39:31Z","timestamp":1737423571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immunobiology of MPox Infection and Its Management: Experience From Developing Nations"],"prefix":"10.1002","volume":"35","author":[{"given":"Om Saswat","family":"Sahoo","sequence":"first","affiliation":[{"name":"Department of Biotechnology National Institute of Technology  Durgapur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daina","family":"Sapam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Ajmeria","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiya","family":"Aidasani","sequence":"additional","affiliation":[{"name":"Department of Biotechnology National Institute of Technology  Durgapur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3600-6554","authenticated-orcid":false,"given":"Ruby","family":"Dhar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-8729","authenticated-orcid":false,"given":"Subhradip","family":"Karmakar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106705"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1066425"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2541"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202208_29436"},{"key":"e_1_2_17_6_1","unstructured":"D.Kuritzkes Mpox Declared Public Health Emergency of International Concern. 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