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Commonly implicated arboviruses include dengue virus (DENV), Zika virus (ZIKV), chikungunya virus (CHIKV), West Nile virus (WNV), and yellow fever virus (YFV). These viruses exhibit specific tropisms, targeting organs such as the central nervous system (CNS), liver, and vasculature. Immune responses in children, characterised by an underdeveloped adaptive system and enhanced innate immunity, can exacerbate inflammation and increase susceptibility to severe outcomes such as dengue hemorrhagic fever (DHF), congenital Zika syndrome (CZS), and neuroinvasive complications. Maternal antibodies, antibody\u2010dependent enhancement (ADE), and immature barriers, such as the blood\u2010brain barrier, further contribute to disease severity. This review highlights the virological and immunological nuances of arboviral pathophysiology in paediatric patients, emphasising the need for age\u2010specific diagnostic, therapeutic, and preventive strategies to mitigate the burden of these infections.<\/jats:p>","DOI":"10.1002\/rmv.70016","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T23:24:33Z","timestamp":1739316273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Manifestation of Arboviruses in Paediatrics"],"prefix":"10.1002","volume":"35","author":[{"given":"Mu","family":"Pang","sequence":"first","affiliation":[{"name":"The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine (Shenzhen Traditional Chineses Medicine Hospital)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010zhe","family":"Sun","sequence":"additional","affiliation":[{"name":"Research Center for Drug Safety Evalution of Hainan Province Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"He","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine (Shenzhen Traditional Chineses Medicine Hospital)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine (Shenzhen Traditional Chineses Medicine Hospital)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1461-7611","authenticated-orcid":false,"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine (Shenzhen Traditional Chineses Medicine Hospital)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"e_1_2_16_2_1","first-page":"25","article-title":"Emerging and Re\u2010emerging Arboviral Diseases as a Global Health Problem. 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