{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:04:18Z","timestamp":1773777858762,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Zika virus (ZIKV) is a virus transmitted by arthropods that exhibits considerable pathogenicity, resulting in a significant health and economic impact worldwide. A rise in congenital anomalies has been noted in kids born to mothers who have infections during pregnancy, alongside a rise in neurological symptoms in adults. In this study, we reassessed the data on brain abnormalities in maternal infection with ZIKV during pregnancy through a systematic review and meta\u2010analysis. A thorough search was carried out in the PubMed, Scopus, Web of Science and Embase databases to extract pertinent published data up to November, 2024. In this meta\u2010analysis, 14 studies with 912 individuals were incorporated. Subgroup analyses, depending on the maternal age, gestational age at detection of brain abnormalities, the time of ZIKV diagnosis, type of sample and birth weight at delivery, were performed. Critical appraisal was completed using the Newcastle\u2013Ottawa Scale (NOS) tools. In this analysis, we identified 14 studies that reported brain abnormalities in newborn infants with ZIKV\u2010infected pregnant women, of which 58% studies were from Brazil. The overall birth defect with brain abnormalities was found to be (1.94 [95% CI: 1.3\u20132.7],\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.00). Of the most common brain abnormalities, microcephaly (OR: 2.7 [95% CI 1.5\u20134.7],\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.00), ventriculomegaly (OR: 1.7 [95% CI 0.91\u20133.3],\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.09) and corpus callosal anomaly (OR: 1.8 [95% CI 1.02\u20133.3],\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.04) had highest the risk in children with ZIKV\u2010infected pregnant women. No publication bias was found when applying the Begg's rank correlation and Egger's linear regression tests (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a01 and\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.44, respectively). subgroups of maternal age \u2265\u00a030 years and gestational week of ZIKV diagnosis \u2265\u00a025 weeks are important in zika\u2010associated birth defects. This systematic review and meta\u2010analysis evidenced a high risk of brain defects in ZIKV\u2010infected pregnant women. Maternal age and gestational week of ZIKV diagnosis may modify this risk.\n                  <\/jats:p>","DOI":"10.1002\/rmv.70019","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:53:04Z","timestamp":1741632784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Zika Virus\u2010Related Birth Defects and Neurological Complications: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"35","author":[{"given":"Fang","family":"Ba","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology The First Hospital of Chinese Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silu","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The First Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shengjing Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4991-9718","authenticated-orcid":false,"given":"Yanli","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Forth Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2020.01.015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010017\u20100010\u20108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006952"},{"key":"e_1_2_10_5_1","volume-title":"The Arboviruses: Epidemiology and Ecology","author":"Monath T. 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