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CHPV paediatric encephalitis reported in 2003\u20132004 in central and south\u2010western parts of India had a case fatality rate of \u223c70%. CHPV infection leads to high\u2010grade fever, vomiting, altered sensorium, generalised convulsions, decerebrate posture and coma. Neuroinflammation is the hallmark of CHPV infection and has a pronounced effect on cerebral and brainstem regions. Currently, there are no vaccines or treatments available for CHPV infection. Although previous studies have provided insights into the virus's pathology and host\u2010pathogen interactions, the precise molecular mechanisms underlying CHPV pathogenesis are poorly understood. Understanding molecular pathogenesis is crucial for developing efficacious therapies and preventive measures. The review summarises CHPV epidemiology, transmission, genome structure, replication, pathogenesis and the latest antiviral therapies and vaccine developments.\n                  <\/jats:p>","DOI":"10.1002\/rmv.70032","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T08:04:21Z","timestamp":1742976261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Biological and Pathogenic Blueprint of Chandipura Virus"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-019X","authenticated-orcid":false,"given":"Neha","family":"Pandey","sequence":"first","affiliation":[{"name":"Molecular Biology Unit Faculty of Medicine Institute of Medical Sciences Banaras Hindu University  Varanasi India"},{"name":"Dr. B R Ambedkar Centre for Biomedical Research (ACBR) University of Delhi  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8802-1169","authenticated-orcid":false,"given":"Sunit K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Molecular Biology Unit Faculty of Medicine Institute of Medical Sciences Banaras Hindu University  Varanasi India"},{"name":"Dr. B R Ambedkar Centre for Biomedical Research (ACBR) University of Delhi  Delhi India"},{"name":"Delhi School of Public Health (DSPH) University of Delhi  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"issue":"12","key":"e_1_2_12_2_1","first-page":"1295","article-title":"Chandipura: A New Arbovirus Isolated in India From Patients With Febrile Illness","volume":"55","author":"Bhatt P. 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