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These viruses manipulate mTOR\u00a0complexes through specific viral proteins, such as DENV NS5 activating mTORC2 to suppress apoptosis and ZIKV NS4A\/NS4B inhibiting Akt\u2010mTORC1 signalling to impair neurogenesis while promoting autophagy. JEV NS1\/NS1\u2032 disrupts the blood\u2010brain barrier by inducing autophagy\u2010mediated degradation of tight junction proteins via mTOR suppression, contributing to encephalitis. These interactions result in severe pathological outcomes, including immune evasion, metabolic reprogramming, apoptosis suppression, and neurological disorders like microcephaly. Targeting mTOR has emerged as a promising therapeutic approach for arbovirus infections. Rapamycin and its derivatives reduce viral replication and improve survival in preclinical models, while repurposed drugs like niclosamide and chloroquine exhibit antiviral effects against ZIKV. ATP\u2010competitive inhibitors such as Torin\u20101 and natural compounds like resveratrol expand the therapeutic landscape. Combination therapies pairing mTOR inhibitors with antivirals or immune modulators may provide synergistic benefits. This review highlights the molecular mechanisms underlying arbovirus manipulation of mTOR signalling and emphasises the potential of tailored therapeutic interventions targeting these pathways to mitigate arbovirus\u2010associated diseases.<\/jats:p>","DOI":"10.1002\/rmv.70037","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T01:35:23Z","timestamp":1746236123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["mTOR Signalling in Arbovirus Infections: Molecular Mechanisms and Therapeutic Opportunities"],"prefix":"10.1002","volume":"35","author":[{"given":"Suad A.","family":"Alghamdi","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alissa","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6635-3102","authenticated-orcid":false,"given":"Abdullah","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121241229847"},{"key":"e_1_2_17_3_1","volume-title":"Arbovirus Encephalitides. 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