{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:22:45Z","timestamp":1789435365929,"version":"build-2803163510"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Emerging and re\u2010emerging RNA viruses represent a persistent and evolving global health threat. While primarily recognized for their acute systemic or respiratory illnesses, a growing body of evidence implicates several of these pathogens in the development or exacerbation of bone\u2010related diseases. This review critically describes the multifaceted roles of selected major RNA viruses\u2014Dengue Virus (DENV), Chikungunya Virus (CHIKV), and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS\u2010CoV\u20102)\u2013 in bone\u2010related diseases. It discusses the current understanding of the clinical manifestations, ranging from arthralgia and arthritis to more severe outcomes such as osteopenia, osteoporosis, and bone erosions. The review describes the potential pathogenic mechanisms, including direct viral infection of bone cells (osteoblasts, osteoclasts, and osteocytes), as well as virus\u2010induced dysregulation of host immune responses that lead to pro\u2010inflammatory cytokine storms and altered signalling pathways, collectively driving aberrant bone remodelling. By discussing current knowledge, this review aims to highlight the significant, yet often underappreciated, impact of these RNA viruses on bone health, identify existing knowledge gaps, and underscore the need for further mechanistic research to inform targeted therapeutic and preventive strategies that reduce bone morbidity in affected populations.<\/jats:p>","DOI":"10.1002\/rmv.70053","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T04:28:13Z","timestamp":1753504093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Role of Emerging\/Re\u2010Emerging RNA Viruses in Bone\u2010Related Diseases With a Focus on DENV, CHIKV, and SARS\u2010CoV\u20102"],"prefix":"10.1002","volume":"35","author":[{"given":"Jinxi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital Medical College of Zhejiang University  Hangzhou China"},{"name":"Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0335-8927","authenticated-orcid":false,"given":"Jianglong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","article-title":"Emerging and Re\u2010emerging Viral Infections in the 21st Century: Microbiological and Public Health Perspectives","volume":"10","author":"Sannathimmappa M. 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