{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:15:51Z","timestamp":1775081751425,"version":"3.50.1"},"reference-count":81,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF22H060032"],"award-info":[{"award-number":["LGF22H060032"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Arthropod\u2010borne viruses (arboviruses), such as Chikungunya virus (CHIKV), Zika virus (ZIKV), and Dengue virus (DENV), represent significant global health threats. Beyond their acute systemic illnesses, many arboviral infections are characterized by debilitating and often chronic musculoskeletal complications, including arthralgia, arthritis, myalgia, and bone pain. Evidence suggests that these pathologies may stem, at least in part, from the viruses' direct or indirect interference with fundamental cellular processes governing skeletal homoeostasis, particularly osteogenesis (bone formation) and bone remodelling. Key signalling pathways critical for osteoblast differentiation and function, such as Wnt\/\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010catenin, Bone Morphogenetic Protein (BMP), Notch, and Receptor Activator of Nuclear Factor kappa\u2010B Ligand (RANKL) pathways, are potential targets for viral manipulation or dysregulation by the host inflammatory response. This article reviews the current understanding of how arboviruses might interact with osteogenesis\u2010associated signalling pathways, explores the link between this interaction and musculoskeletal disease, and proposes that targeting these pathways could represent a novel therapeutic strategy to mitigate the long\u2010term skeletal sequelae of arboviral infections.\n                  <\/jats:p>","DOI":"10.1002\/rmv.70055","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:24:08Z","timestamp":1752719048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arboviruses and Osteogenesis\u2010Associated Signalling Pathways: A Potential Therapeutic Target for Musculoskeletal Complications"],"prefix":"10.1002","volume":"35","author":[{"given":"Jian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuying","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sir Run Run Shaw Hospital, Medical College of Zhejiang University Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Hangzhou Ninth People's Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.10.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2018.06.021"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"397","article-title":"Emergence of Mosquito\u2010Borne Viruses in Iran and Adjacent Countries: The Case of Chikungunya","volume":"11","author":"Bakhshi H.","year":"2023","journal-title":"Journal of Health Sciences & Surveillance System"},{"key":"e_1_2_9_5_1","volume-title":"Is Zika Virus the Definitive Culprit in Cases of Microcephaly?","author":"Icheku V.","year":"2017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447782"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2732501620939515"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974\u2010360x.2021.00406"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010023\u201001586\u20106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3254"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.09.065"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.09.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3074"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.2929"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012\u20101732"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.154"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00543\u201016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00347\u201020"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.07.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713087"},{"issue":"3","key":"e_1_2_9_21_1","first-page":"211","article-title":"Chikungunya Virus Infection: An Overview","volume":"36","author":"Caglioti C.","year":"2013","journal-title":"New Microbiologica"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01430\u201023"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis368"},{"key":"e_1_2_9_24_1","volume-title":"Chikungunya Virus Infection\u2010Associated Bone and Joint Disease","author":"Goupil B. 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