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Several emerging and re\u2010emerging viral infections, such as those caused by Zika virus (ZIKV), dengue virus (DENV), severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), and monkeypox virus (MPXV), have been involved in the development of various ophthalmic disorders including uveitis, conjunctivitis, retinitis, optic neuritis, and more severe vision\u2010threatening complications. The present review comprehensively describes the ophthalmic manifestations linked to these viruses, with a primary focus on their underlying pathogenesis, diverse clinical presentations, and the intricate potential mechanisms of viral invasion into ocular tissues. Describing the ocular involvement of emerging and re\u2010emerging viral pathogens, particularly how they target and affect the ocular system, is critical for early diagnosis, appropriate management, and reducing long\u2010term visual manifestations in affected patients. This review aims to address existing gaps in clinical knowledge and support timely ophthalmological management during emerging viral outbreaks.<\/jats:p>","DOI":"10.1002\/rmv.70056","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:43:58Z","timestamp":1752720238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Overview of Ophthalmic Complications Associated With Emerging\/Re\u2010Emerging Viruses: Focus on ZIKV, DENV, SARS\u2010CoV\u20102, and MPXV"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5777-4758","authenticated-orcid":false,"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology the First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory the Affiliated Hospital of Changchun University of Chinese Medicine  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infection Control the Affiliated Hospital of Changchun University of Chinese Medicine  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2460-6899","authenticated-orcid":false,"given":"Lingling","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology the First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003467"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(16)32518\u20101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1202.050274"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120929961"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010022\u201002195\u2010z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.382"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1224"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1869\u20105760\u20103\u201035"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1772313"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00058\u201012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1749"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10112224"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/v17050637"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00014\u201016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2017.04.003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2024.2314086"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2021.01.009"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-53643-9_4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256\u2010018\u20101679\u2010y"},{"key":"e_1_2_9_21_1","volume-title":"Current Concepts in Zika Research","author":"Mart\u00ednez\u2010Pulgar\u00edn D. 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