{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:08:30Z","timestamp":1768716510381,"version":"3.49.0"},"reference-count":118,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dengue virus (DENV) and Monkeypox virus (MPXV) are two major re\u2010emerging viral pathogen, which have recently gained global attention, mainly in light of their potential for widespread transmission and the ability to cause various complications. While the characteristic manifestations of these infections comprise lymphadenopathy, fever, and rash, recent studies suggest a darker dimension, neuropsychiatric complications, which are a hallmark of neurovirulent viral pathogens. However, current evidence suggests that these complications, which may vary from mild to critical conditions such as meningitis and encephalitis, are not well understood, posing marked challenges in the realm of diagnosis and treatment. In other words, while neuropsychiatric presentations of DENV and MPXV appear as an area of concern, diagnosing these manifestations remains challenging owing to their general characteristics and overlap with those of other pathological conditions and the lack of the central nervous system (CNS)\u2010focused diagnostic tools. This can delay early detection and subsequent appropriate surveillance of DENV\u2010 and MPXV\u2010associated neuropsychiatric complications. The present review focuses on describing various DENV\u2010 and MPXV\u2010associated neuropsychiatric complications, the underlying pathophysiological mechanisms, and their current diagnostic challenges.<\/jats:p>","DOI":"10.1002\/rmv.70058","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:34:06Z","timestamp":1752719646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuropsychiatric Complications of Two Re\u2010Emerging Viruses (DENV and MPXV): Current Evidence, Pathophysiological Mechanisms, and Diagnostic Challenges"],"prefix":"10.1002","volume":"35","author":[{"given":"Chang\u2010Hai","family":"Fu","sequence":"first","affiliation":[{"name":"Teaching Center for Basic Medical Experiment of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Chi","sequence":"additional","affiliation":[{"name":"Journal Center of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The First Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Ming","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Hospital of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Journal Center of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2178-9713","authenticated-orcid":false,"given":"Li\u2010Jiao","family":"Qiao","sequence":"additional","affiliation":[{"name":"Journal Center of China Medical University  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974\u2010360X.2021.00406"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellin.2024.100185"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2023.10.004"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010025\u201003921\u20106"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad415"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972\u20102327.91946"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.4081\/ni.2012.e15"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010022\u201001213\u20107"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_157_21"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.01.011"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02036-5"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2008.03.011"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.54.256"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101560200030"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3473-6"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-006-0475-6"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3604"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.05.068"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/aam.aam_30_17"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103206"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.161990"},{"key":"e_1_2_15_23_1","first-page":"1","article-title":"Guillain\u2013Barre Syndrome Following Dengue Fever and Literature Review","volume":"8","author":"Dmpuk R.","year":"2015","journal-title":"BMC Research Notes"},{"issue":"1","key":"e_1_2_15_24_1","first-page":"149","article-title":"Dengue\u2010induced Guillain\u2013Barre Syndrome: A Case Series. The Egyptian Journal of Neurology","volume":"59","author":"Imtiaz H.","year":"2023","journal-title":"Psychiatry and Neurosurgery"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2025.e02160"},{"issue":"1","key":"e_1_2_15_26_1","first-page":"25","article-title":"Isolated Unilateral Sixth Cranial Nerve Palsy: A Rare Presentation of Dengue Fever","volume":"11","author":"Mazliha M.","year":"2016","journal-title":"Malaysian Family Physician: the Official Journal of the Academy of Family Physicians of Malaysia"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05430-8"},{"key":"e_1_2_15_28_1","doi-asserted-by":"crossref","unstructured":"RissardoJ. P. ByrojuV. V. CapraraA. L. F. \u201cA Scoping Review of Neurological Manifestations of Dengue Virus Infection besides Cerebrovascular Disorders.\u201d (2024) https:\/\/doi.org\/10.20944\/preprints202412.0936.v1.","DOI":"10.20944\/preprints202412.0936.v1"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/02537176211022571"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2023.341"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.2190\/PM.44.3.b"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.10.011"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13033-018-0202-6"},{"issue":"1","key":"e_1_2_15_34_1","first-page":"36","article-title":"A Case of Acute Psychosis Following Dengue Fever","volume":"16","author":"Shahzad W.","year":"2021","journal-title":"Pakistan Journal of Neurological Sciences (PJNS)."},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-2870.202104"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2013.11.002"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20150074"},{"key":"e_1_2_15_38_1","first-page":"10","article-title":"Dengue Virus Infection of Blood\u2013Brain Barrier Cells: Consequences of Severe Disease","author":"Calder\u00f3n\u2010Pel\u00e1ez M.\u2010A.","year":"2019","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27670"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2535"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1114525"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3491"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365\u2010023\u201001121\u20107"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10140\u2010022\u201002108\u20103"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101644"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcac192"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.2.293"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/425039"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa143"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010024\u201009000\u20100"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7138e1"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00741\u20101"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28755"},{"key":"e_1_2_15_54_1","doi-asserted-by":"crossref","unstructured":"NarayanR. N. GreenbergB. \u201cTransverse Myelitis. Myelopathy: A Guide to Diagnosis and Treatment.\u201d (2022):135\u2010154.","DOI":"10.1007\/978-3-030-99906-3_7"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010025\u201003921\u20106"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2023.578190"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001146"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2023-258334"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2426659"},{"issue":"9","key":"e_1_2_15_60_1","first-page":"1781","article-title":"Parsonage\u2010Turner Syndrome Following Monkeypox Infection and Vaccination","volume":"52","author":"Nimura C. A.","year":"2023","journal-title":"Journal of Sleep Research"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11420\u2010010\u20109176\u2010x"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.51.4.1110"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.163386"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcac192"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26597"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(15)00042\u20103"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028\u2010012\u20109695\u2010z"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00008414"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013\u20100929"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2019.10549"},{"issue":"35","key":"e_1_2_15_71_1","article-title":"Neurological Manifestations of an Emerging Zoonosis\u2014Human Monkeypox Virus","volume":"102","author":"Khan S. A.","year":"2023","journal-title":"A systematic review"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638237.2020.1757052"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.1060"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(19)30294\u20104"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106913"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104771"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(22)00228\u20106"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29198"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.4102\/jphia.v16i1.786"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796021000214"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1027\/0227\u20105910\/a000753"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14091894"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737\u2010022\u201001288\u20108"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dscb.2024.100169"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010022\u201011339\u2010w"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1009.040310"},{"key":"e_1_2_15_87_1","doi-asserted-by":"crossref","unstructured":"HutsonC. L. LeeK. N. AbelJ. et\u00a0al. \u201cMonkeypox Zoonotic Associations: Insights From Laboratory Evaluation of Animals Associated With the Multi\u2010State US Outbreak.\u201d76 no.4(2007):757\u2010768.","DOI":"10.4269\/ajtmh.2007.76.757"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700143"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.11.015"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060533"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315653121"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156560"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2021.247"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.1049724"},{"key":"e_1_2_15_95_1","doi-asserted-by":"crossref","unstructured":"McCuddyM. KelkarP. ZhaoY. WicklundD. \u201cAcute Demyelinating Encephalomyelitis (ADEM) in COVID\u201019 Infection: A Case Series.\u201d ;68 no.5(2020):1192\u20101195.","DOI":"10.4103\/0028-3886.299174"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205019666220908084559"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2443"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1086\/427805"},{"issue":"7","key":"e_1_2_15_99_1","article-title":"Pathogenesis of Fulminant Monkeypox With Bacterial Sepsis After Experimental Infection With West African Monkeypox Virus in a Cynomolgus Monkey","volume":"7","author":"Nagata N.","year":"2014","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"10","key":"e_1_2_15_100_1","article-title":"Sepsis\u2010induced Multi\u2010Organ Dysfunction Syndrome\u2014A Mechanistic Approach","volume":"1","author":"Spapen H. D.","year":"2017","journal-title":"JECCM"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2023.00256"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02178-4"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.38163"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13010249"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11092287"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2934"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001370"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.10.017"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102020\u2010238078"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2016.05.007"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381945"},{"issue":"4","key":"e_1_2_15_112_1","first-page":"1027","article-title":"Human Monkeypox: Epidemiologic and Clinical Characteristics","volume":"33","author":"Petersen E.","year":"2019","journal-title":"diagnosis, and prevention"},{"issue":"2","key":"e_1_2_15_113_1","article-title":"The Changing Epidemiology of Human Monkeypox\u2014A Potential Threat?","volume":"16","author":"Bunge E. M.","year":"2022","journal-title":"A systematic review"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1086\/498115"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1086\/505880"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051186"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.2196\/46489"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106943"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.37547\/tajssei\/Volume06Issue11\u201014"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:36:03Z","timestamp":1764480963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.70058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":118,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/rmv.70058"],"URL":"https:\/\/doi.org\/10.1002\/rmv.70058","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70058"}}