{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:27:15Z","timestamp":1790083635549,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Kidney transplantation is recognised by the World Health Organisation as the most effective therapy for end\u2010stage renal disease, offering substantial improvements in survival and quality of life. However, the immunosuppression required to prevent graft rejection predisposes recipients to opportunistic infections, among which cytomegalovirus (CMV) remains a leading cause of morbidity and mortality. To determine the incidence of CMV infection in kidney transplant recipients and identify clinical and laboratory predictors and associated risk factors. A systematic review and meta\u2010analysis, registered in PROSPERO (CRD42024524165), was conducted in accordance with PRISMA guidelines. PubMed, Web of Science, and LILACS databases were searched up to 6 March 2024 for cohort studies reporting CMV incidence post\u2010kidney transplantation. Methodological quality was assessed using the Newcastle\u2013Ottawa Scale (NOS). Publication bias was evaluated using funnel plots, Egger's test, Kendall's tau, and the fail\u2010safe N. Fifteen studies met the inclusion criteria, comprising 3888 patients with a mean age of 45.1\u00a0years and a mean follow\u2010up of 7.14\u00a0months. The pooled incidence of CMV infection was 42% (95% CI: 30%\u201354%), with high heterogeneity (I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a098.75%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Sensitivity analysis confirmed the robustness of the results, and no significant publication bias was detected. The main risk factors were: advanced age, paediatric age (&lt;\u00a05\u00a0years), donor\u2013recipient serodiscordance (D+\/R\u2212), post\u2010transplant lymphopenia, and reduced cell\u2010specific immunity defect. CMV infection remains a common and clinically significant complication following kidney transplantation. With a high incidence and strong association with specific laboratory and clinical predictors. Individualised prevention strategies and early virological and immunological monitoring, especially in high\u2010risk groups, are essential to reduce morbidity and mortality and preserve graft function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Protocol Registration<\/jats:title>\n                    <jats:p>PROSPERO: CRD42024524165<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/rmv.70092","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T17:44:42Z","timestamp":1767462282000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence of Cytomegalovirus (CMV) Infection in After Kidney Transplant Patients: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"36","author":[{"given":"Gleice K.","family":"Jesus","sequence":"first","affiliation":[{"name":"Postgraduate Program in Medicine and Health Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3ger","family":"Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medicine and Health Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel O.","family":"Franco","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medicine and Health Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleyde C. S.","family":"Marconi","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medicine and Health Federal University of Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B.","family":"Arriaga","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Bahiana de Infectologia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo M.","family":"Netto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medicine and Health Federal University of Bahia  Salvador Brazil"},{"name":"Funda\u00e7\u00e3o Bahiana de Infectologia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/1980\u2010220x\u2010reeusp\u20102021\u20100255"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0101\u201028002010000100013"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.05.010"},{"key":"e_1_2_12_5_1","unstructured":"M.Paulina Salazar E A.Alba G A.Deluchi B et\u00a0al. \u201cCytomegalovirus Infection and Disease in Children Undergoing Solid Organ Transplantation \u201d [Internet] (April 2008) www.sochinf.cl."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13516"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn355"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2014.09.018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.12.001"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02763869.2019.1588072"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_12_13_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G.","year":"2000"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.9.2069\u20102075.1990"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010642\u201077423\u20102_8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0966\u20103274(97)80050\u20100"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u2010879X1999000800004"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.09.007"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000264999.71318.2b"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.12.029"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.08.015"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2023.04.042"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmv.70092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:09:04Z","timestamp":1773007744000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.70092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rmv.70092"],"URL":"https:\/\/doi.org\/10.1002\/rmv.70092","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70092"}}