{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:06Z","timestamp":1786978446108,"version":"build-2736575974"},"reference-count":85,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oncogenic viruses, with their significant capacity to drive malignant transformation, are currently known as a major factor involved in cardiovascular diseases (CVDs) by intricate immunometabolic and inflammatory processes. In this context, viral pathogens such as Hepatitis B and C viruses (HBV\/HCV), Human Cytomegalovirus (HCMV), Human Papillomavirus (HPV), Epstein\u2013Barr Virus (EBV), and Human T\u2010Lymphotropic Virus (HTLV) have been detected in vascular tissues and are hypothesised to contribute to endothelial dysfunction, atherogenesis, and myocarditis. These viruses can modulate host cell signalling, induce chronic inflammation, and promote oxidative stress, thereby accelerating vascular remodelling and plaque instability. Emerging evidence also suggests that viral oncogenes interfere with cardiomyocyte survival pathways and disrupt vascular smooth muscle cell homoeostasis. Despite growing interest, the causal relationship between oncoviral infection and cardiovascular disease remains underexplored, and current clinical guidelines do not address viral\u2010driven cardiopathology. This review synthesises current mechanistic insights and highlights epidemiological links, aiming to bridge gaps between oncology and cardiovascular virology. Understanding the dual oncogenic and cardiotropic potential of these viruses may open new therapeutic perspectives and support the development of targeted antiviral and immunomodulatory strategies for cardiovascular prevention in high\u2010risk populations.<\/jats:p>","DOI":"10.1002\/rmv.70097","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:09:55Z","timestamp":1767866995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oncoviruses as Emerging Players in Cardiovascular Pathogenesis: Evidence, Mechanisms and Clinical Perspectives"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2326-029X","authenticated-orcid":false,"given":"Chuang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-9474","authenticated-orcid":false,"given":"Zhuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Internal Medicine the Second Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2025.101371"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2088"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.95369"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.14218\/jcth.2017.00021"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612827666210426094502"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13101924"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1621338"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988473.ch1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2004.09.003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2741\/4633"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.619690"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1818"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01183\u201020"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.945016"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113351"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103893"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890802186913"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2003"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj\u201011\u20101184"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.37349\/ec.2023.00014"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca\u20102020\u20100188"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.10723"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102634"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.04.029"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2015.05.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.4.e20"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112459"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1643502"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.908663"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010150"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.77.903.4"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2131"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/cd9.0000000000000116"},{"key":"e_1_2_11_35_1","first-page":"1083","volume-title":"Human Papilloma Virus and Atherosclerotic Cardiovascular Disease","author":"Chan N. 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