{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:20:00Z","timestamp":1784647200971,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The recent review by Zhang et\u00a0al. provides a valuable consolidation of clinical evidence linking Dengue virus (DENV), Chikungunya virus (CHIKV), and SARS\u2010CoV\u20102 to bone\u2010related diseases. While their work aptly highlights this emerging clinical paradigm, our letter offers a critical analysis to propel the field from descriptive association to mechanistic causation. We identify and dissect several substantive gaps in the current narrative. Firstly, we challenge the prevailing yet often circumstantial evidence for direct viral infection of bone cells, arguing for the need to distinguish between productive infection and passive viral presence. Secondly, we call for a more nuanced deconstruction of the \u201ccytokine storm\u201d hypothesis, urging the identification of master regulators and a clearer delineation between viral persistence and virally\u2010induced autoimmunity in driving chronic pathology, such as post\u2010CHIKV arthritis. Furthermore, we emphasise the critical need for longitudinal studies to define the long\u2010term trajectory of bone health post\u2010SARS\u2010CoV\u20102 infection, distinguishing transient from permanent metabolic defects. Finally, we propose a unified, comparative research framework utilising advanced models to uncover fundamental principles of virus\u2010bone interactions. This critical perspective underscores the necessity of a deeper, mechanism\u2010driven investigative agenda to inform future therapeutic strategies.<\/jats:p>","DOI":"10.1002\/rmv.70099","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:34:48Z","timestamp":1768296888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Defining Viro\u2010Osteopathology: Unresolved Mechanistic Questions in the Pathogenesis of RNA Virus\u2010Associated Bone Disorders"],"prefix":"10.1002","volume":"36","author":[{"given":"Lin","family":"Yu","sequence":"first","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Southwest Medical University  Luzhou Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DuJiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Southwest Medical University  Luzhou Sichuan Province China"},{"name":"Center for Orthopedic Diseases Research Chinese Medicine Hospital  Luzhou Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Ye","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Southwest Medical University  Luzhou Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-0572","authenticated-orcid":false,"given":"GuoYou","family":"Wang","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Southwest Medical University  Luzhou Sichuan Province China"},{"name":"Center for Orthopedic Diseases Research Chinese Medicine Hospital  Luzhou Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.70053"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.178260"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjae048"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010024\u201001008\u20106"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113585"}],"container-title":["Reviews in Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rmv.70099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rmv.70099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:09:02Z","timestamp":1773007742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rmv.70099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/rmv.70099"],"URL":"https:\/\/doi.org\/10.1002\/rmv.70099","archive":["Portico"],"relation":{},"ISSN":["1052-9276","1099-1654"],"issn-type":[{"value":"1052-9276","type":"print"},{"value":"1099-1654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70099"}}