{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:48:31Z","timestamp":1792086511925,"version":"4.4.0"},"reference-count":97,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Increasing outbreaks of coronaviruses underscore the importance of antivirals and vaccines that can combat a wide range of coronaviruses. Neutralising antibodies (nAbs), along with vaccines and small\u2010molecule drugs, are among the most promising treatments and prevention options against coronaviruses. Here, we focus on Middle East Respiratory Syndrome coronavirus (MERS\u2010CoV) and discuss receptor usage and current progress in antibody research against MERS\u2010CoV infections. First detected in Saudi Arabia and Jordan in 2012, MERS\u2010CoV is a lethal zoonotic pathogen. MERS\u2010CoV infections have been reported by 27 countries between April 2012 till now, with 953 deaths (\u223c35% mortality) (5 new infections and 4 fatalities reported as of 1 October 2024). WHO identified MERS\u2010CoV as a high\u2010threat pathogen due to its severity, high mortality rate, and potential for epidemic or pandemic spread with recent outbreaks and deaths raising more concerns amidst the COVID\u201019 pandemic. As of now, there is no antiviral drugs or vaccine against MERS\u2010CoV available. Here we provide a perspective on receptor usage, the risk of MERS\u2010CoV and other CoVs evolution on future pandemics, and the mechanisms of MERS\u2010CoV\u2010derived nAbs. We offer insight into how these antibodies cross\u2010react and cross\u2010neutralise by analysing available structures of spike glycoprotein\u2013antibody complexes. This review provides an update and a basis for the development of antibodies and vaccines for MERS\u2010CoV, and possibly for the designing of next\u2010generation pan\u2010coronavirus vaccines and antivirals.<\/jats:p>","DOI":"10.1002\/rmv.70113","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:47:35Z","timestamp":1772988455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Structural Basis of MERS\u2010CoV Receptor Interactions and Antibody Neutralisations"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-7849","authenticated-orcid":false,"given":"Edem","family":"Gavor","sequence":"first","affiliation":[{"name":"Department of Biological Sciences National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeu Khai","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hariharan","family":"Sivaraman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Er Shi","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-5326","authenticated-orcid":false,"given":"J.","family":"Sivaraman","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa030747"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1211721"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00187\u201020"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802879115"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00473\u201012"},{"key":"e_1_2_13_7_1","unstructured":"WHO.Middle East Respiratory Syndrome Coronavirus (MERS\u2010CoV). 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