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While public health efforts have largely focused on women due to its link to cervical cancer, HPV also poses significant risks to men, particularly in the oropharyngeal regions. HR\u2010HPV prevalence in men is high, with global estimates of 21% for male genital infections. While the HPV vaccination programme has expanded to include boys, challenges remain, including a decline in vaccine uptake due to COVID\u201019 disruptions, vaccine hesitancy, and misinformation. These barriers hinder the full potential of vaccination efforts. Furthermore, HPV transmission is complex and multifactorial, making it difficult to track, while its prevalence, clearance, and persistence vary based on factors such as sexual behaviour and immune status. Additionally, data from lower socio\u2010economic regions is limited, highlighting a critical gap in research. Specific data on these epidemiological characteristics for male patients is lacking, prompting the need for gender\u2010balanced approaches. Here, we explore the prevalence, risks, and public health implications of high\u2010risk HPV (HR\u2010HPV) in men. We suggest a more inclusive approach to HPV prevention, emphasising the need for targeted vaccination and screening programs for men. A gender\u2010neutral approach is crucial to reducing the global burden of HPV\u2010related diseases and moving closer to the goal of eradicating HPV infections worldwide.<\/jats:p>","DOI":"10.1002\/rmv.70115","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:24:34Z","timestamp":1771068274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["High\u2010Risk HPV in Men: A Hidden Threat to Public Health?"],"prefix":"10.1002","volume":"36","author":[{"given":"Keesha L.","family":"Coker","sequence":"first","affiliation":[{"name":"School of Life Sciences University of Sussex  Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-5450","authenticated-orcid":false,"given":"Ethan L.","family":"Morgan","sequence":"additional","affiliation":[{"name":"School of Life Sciences University of Sussex  Brighton UK"},{"name":"Tumour 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