{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:01:09Z","timestamp":1787698869180,"version":"build-2784847793"},"reference-count":94,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reviews in Medical Virology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chandipura virus, a neurotropic RNA virus transmitted by\n                    <jats:italic>Phlebotomus sandflies<\/jats:italic>\n                    , remains an under\u2010recognised cause of acute paediatric encephalitis in India. The 2024 outbreak, with 245 confirmed cases and 82 deaths, underscores its ongoing public health relevance. This review provides an integrated analysis of CHPV, encompassing its epidemiological distribution in India, host\u2013agent\u2013environment transmission dynamics, molecular and cellular pathogenesis, clinical presentation, diagnostic modalities, therapeutic options, and vaccine research. Evidence from 1950 to 2025, drawn from peer\u2010reviewed studies, outbreak reports, and national surveillance databases, shows that CHPV primarily affects children younger than 15\u00a0years and causes abrupt fever, seizures, and coma within 24\u201348\u00a0h. The virus breaches the blood\u2013brain barrier through cytokine\u2010mediated permeability and induces neuronal apoptosis via Fas\u2010 and NF\u2010\u03baB\u2010linked pathways, while genomic studies demonstrate overall stability across outbreaks. Diagnosis depends on RT\u2010PCR and IgM ELISA, available only in reference laboratories. Experimental antivirals such as favipiravir and recombinant glycoprotein vaccines show promise in animal models but remain untested in humans. Strengthening molecular surveillance, integrating CHPV detection into India's Integrated Disease Surveillance Programme, and investing in antiviral and vaccine development are crucial to reducing the recurring burden of this neglected childhood neurotropic arbovirus.\n                  <\/jats:p>","DOI":"10.1002\/rmv.70119","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:06:45Z","timestamp":1772989605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chandipura Virus: A Neglected Sandfly\u2010Borne Neurotropic Virus in Children \u2010 Insights From Seven Decades of Evidence"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-2150","authenticated-orcid":false,"given":"Ravi Rai","family":"Dangi","sequence":"first","affiliation":[{"name":"Department of Nursing Manikaka Topawala Institute of Nursing Charotar University of Science and 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