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The hyper\u2010activation of the immune response in COVID\u201019 patients is associated with disease progression and severity. As a result, immunomodulatory therapies such as colchicine have been suggested to control exaggerated immune response in COVID\u201019. However, the therapeutic role of colchicine in COVID\u201019 remains a subject of debate due to conflicting evidence. This review highlights both the beneficial and potentially harmful effects of colchicine in the context of COVID\u201019. Notably, the therapeutic advantages of colchicine are linked to the suppression of immune cell over\u2010activation, attenuation of oxidative stress, and prevention of thrombo\u2010inflammatory events. Conversely, colchicine may exert negative effects by disrupting microtubule function, impairing autophagic processes, and inducing mitochondrial dysfunction in COVID\u201019. In conclusion, the overall clinical impact of colchicine plays a critical role in the management of COVID\u201019. However, its dual effects underscore the need for well\u2010designed clinical studies to confirm its safety and efficacy in COVID\u201019 management.<\/jats:p>","DOI":"10.1002\/rmv.70126","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:48:48Z","timestamp":1773006528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colchicine in COVID\u201019: Mechanistic Insights and Clinical Uncertainties"],"prefix":"10.1002","volume":"36","author":[{"given":"Abrar S.","family":"Alsulami","sequence":"first","affiliation":[{"name":"Department of Microbiology College of Medicine Taif University  Taif Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3097-2962","authenticated-orcid":false,"given":"Hayder M.","family":"Al\u2010kuraishy","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Medicine 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